Fig. 7
The IRLS is associated with TME immune cells infiltration. a Cluster heat map of immune-related lncRNAs and 24 types of immune cells stratified by the IRLS risk-level in the TCGA-BLCA cohort. Yellow represents the expression of lncRNAs and levels of immune cells were upregulated while blue indicates downregulated. The relationship between IRLS risk-level and each clinicopathological characteristic were measured with the χ2 test. *p < 0.05, **p < 0.01, ***p < 0.001. b The immune cells network in TCGA-BLCA cohort. The colour of each cluster was: Cell cluster-A, blue; Cell cluster-B, yellow; Cell cluster-C, red; Cell cluster-D, brown. The size of circle indicated the statistical significant on OS for different immune cell type, which was shown as the formula log10 (Log-rank test p value). The lines connecting immune cells indicated cellular interactions. And the thickness of the line represents the correlation coefficient evaluated by spearman correlation analysis. Red represented positive correlation while blue represented negative correlation. c Correlation matrix of IRLS, immune-related lncRNAs and 24 types of immune cell. The blue indicated positive correlation and yellow indicated negative correlation. Shading colour and asterisks represents the value of corresponding correlation coefficients. *p < 0.05, **p < 0.01. d Violin plots demonstrated the correlation between IRLS with the levels of 24 types of immune cell. The p value was indicated in detail