Fig. 7

In LNCaP cells, MCM3AP-AS1 could regulate proliferation and apoptosis by regulating miR-876-5p/WNT5A. c qRT-PCR was used to detect the expression level of MCM3AP-AS1 (a), miR-876-5p (b) and WNT5A (c) in the cells co-transfected with MCM3AP-AS1 plasmid and miR-876-5p mimics. d The proliferation of LNCaP cells was detected by CCK-8 assay. e The proliferation of LNCaP cells was detected by EdU method. f Flow cytometry analysis was used to detect the apoptosis of PCa cells after transfection. g Western blot was used to detect the expression levels of Bcl-2 and Bax. h Graphic Abstract: MCM3AP-AS1 could up-regulate WNT5A via sponging miR-876-5p, thus promoting the proliferation of prostate cancer cells. P < 0.05 was denoted by *, P < 0.01 was denoted by **, and P < 0.001 was denoted by ***