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Table 1 Summarization of the cellular functions of circRNAs in tumorigenesis of OvCa

From: The emerging roles of circular RNAs in ovarian cancer

CircRNAsCircbase IDRole in OvCaCancer phenotypesSponge miRNAsTarget genesReferences
circMUC16hsa_circ_0049116OncogenePromoted proliferation and invasionmiR-199a-5pBeclin1/RUNX1[55]
circCSPP1hsa_circ_0001806OncogenePromoted proliferation, migration, invasion and EMTmiR-1236-3pZEB1[58]
circEPSTI1hsa_circ_0000479OncogenePromoted proliferation, invasion and induced apoptosismiR-942EPSTI1[61]
/hsa_circ_0051240OncogenePromoted proliferation, migration, and invasionmiR-637KLK4[62]
circWHSC1hsa_circ_0001387OncogenePromoted proliferation, migration, invasion, EMT and induced apoptosismiR-145/miR-1182MUC1/hTERT[64]
/hsa_circ_0061140OncogenePromoted proliferation, invasion and EMTmiR-370FOXM1[16]
circHIPK3hsa_circ_0000284Tumor suppressorInhibited proliferation, migration and invasion and promoted apoptosismiR-10a-5p/miR-148b/[77]
circLARP4has_circ_101057Tumor suppressorInhibited proliferation and migrationmiR-513b-5pLARP4[81]
circPLEKHM3hsa_circ_0001095Tumor suppressorInhibited proliferation and migrationmiR-9BRCA1/NAJB6/KLF4[82]
CircITCH/Tumor suppressorInhibited proliferation, migration, invasion and promoted apoptosismiR-10a-α/miR-145RASA1[83, 84]