Table 1 Summarization of the cellular functions of circRNAs in tumorigenesis of OvCa
CircRNAs | Circbase ID | Role in OvCa | Cancer phenotypes | Sponge miRNAs | Target genes | References |
|---|---|---|---|---|---|---|
circMUC16 | hsa_circ_0049116 | Oncogene | Promoted proliferation and invasion | miR-199a-5p | Beclin1/RUNX1 | [55] |
circCSPP1 | hsa_circ_0001806 | Oncogene | Promoted proliferation, migration, invasion and EMT | miR-1236-3p | ZEB1 | [58] |
circEPSTI1 | hsa_circ_0000479 | Oncogene | Promoted proliferation, invasion and induced apoptosis | miR-942 | EPSTI1 | [61] |
/ | hsa_circ_0051240 | Oncogene | Promoted proliferation, migration, and invasion | miR-637 | KLK4 | [62] |
circWHSC1 | hsa_circ_0001387 | Oncogene | Promoted proliferation, migration, invasion, EMT and induced apoptosis | miR-145/miR-1182 | MUC1/hTERT | [64] |
/ | hsa_circ_0061140 | Oncogene | Promoted proliferation, invasion and EMT | miR-370 | FOXM1 | [16] |
circHIPK3 | hsa_circ_0000284 | Tumor suppressor | Inhibited proliferation, migration and invasion and promoted apoptosis | miR-10a-5p/miR-148b | / | [77] |
circLARP4 | has_circ_101057 | Tumor suppressor | Inhibited proliferation and migration | miR-513b-5p | LARP4 | [81] |
circPLEKHM3 | hsa_circ_0001095 | Tumor suppressor | Inhibited proliferation and migration | miR-9 | BRCA1/NAJB6/KLF4 | [82] |
CircITCH | / | Tumor suppressor | Inhibited proliferation, migration, invasion and promoted apoptosis | miR-10a-α/miR-145 | RASA1 |