Table 1 Genes induced by HIF-1α in pancreatic cancer tumorigenesis and progression

LncRNA-NUTF2P3-001

↑LncRNA-NUTF2P3-001, ↓miR-3923, ↑KRAS, ↑cells viability, proliferation and invasion

[26]

LncRNA-CF129

↓LncRNA-CF129, ↑p53, ↑FOXC2, ↑cells proliferation

[28]

STIM1

↑STIM1, ↑cells proliferation, invasion and anchorage independent growth

[10]

PKM2

↑PKM2, ↑glycolysis

[31]

ENO1, PGM2

↑ENO1 and PGM2, ↑glycolysis

[33]

GLUT1, LDHA, HK2

↑GLUT1, LDHA and HK2, ↑glycolysis

[37]

CypA

↑CypA, ↓apoptosis, ↑cells proliferation, migration and invasion

[38]

MiR-21

↑MiR-21, ↓apoptosis, ↑cells proliferation

[40]

MT2-MMP

↑MT2-MMP, ↓apoptosis, ↑cells proliferation and invasion

[42]

MTA2

↑MTA2, ↓E-cadherin, ↑EMT, cells migration and invasion

[49]

Twist

↑Twist, ↓ E-cadherin, ↑EMT and cells proliferation

[50]

Snail

↑Snail, ↓E-cadherin, ↑N-cadherin, ↑EMT, cells migration and invasion

[51]

LncRNA-BX111

↑LncRNA-BX111, ↑ZEB1, MMP-2, ↓E-cadherin, ↑EMT, ↑tumor growth and metastasis

[52]

CD133

↑CD133, ↑tumor stem cell properties, ↑cells migration and invasion

[56]

RER1

↑RER1, ↑N-cadherin, Vimentin and Snail, ↓E-cadherin, ↑Sox2, Bmi1, Lin28 and Nanog, ↑EMT and cancer stem cell-like properties

[58]

ATG5, Beclin1

↑ATG5 and Beclin1, ↑autophagy and cancer stem cell-like properties

[59]

ABCG2

↑ABCG2, ↑ chemoresistance

[64]

NF-κB

↑NF-κB, ↓E-cadherin, ↑N-cadherin, Vimentin, Snail, Twist, ↑EMT and chemoresistance

[65]

CXCR4

↑CXCR4, ↑chemoresistance

[66]

IL-37

↓IL-37, ↑chemoresistance

[68]

VEGF-A

↑VEGF-A, ↑angiogenesis, ↑tumor growth

[73]

STAT3, VEGF-A

↑VEGF-A and STAT3, ↑angiogenesis, ↑tumor growth

[75]

CHC, VEGF-A

↑CHC and VEGF-A, ↑angiogenesis, ↑tumor growth

[77]

VEGF, MMP-2, MMP-9

↑VEGF, MMP-2 and MMP-9, ↑angiogenesis, ↑tumor growth

[78]

ADAM10

↑AMAD10, ↓mMICA, ↑sMICA, ↓NKG2D, ↓NK cells cytotoxicity, ↑immune evasion

[82]

CCL2

↑CCL2, ↑α-SMA, ↑desmoplasia

[85]

SHH

↑SHH, ↑HH signaling, ↑ collagen Ι and fibronectin, ↑desmoplasia

[84, 86]