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Table 1 Genes induced by HIF-1α in pancreatic cancer tumorigenesis and progression

From: Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer

Target genesActing mechanismsReferences
LncRNA-NUTF2P3-001↑LncRNA-NUTF2P3-001, ↓miR-3923, ↑KRAS, ↑cells viability, proliferation and invasion[26]
LncRNA-CF129↓LncRNA-CF129, ↑p53, ↑FOXC2, ↑cells proliferation[28]
STIM1↑STIM1, ↑cells proliferation, invasion and anchorage independent growth[10]
PKM2↑PKM2, ↑glycolysis[31]
ENO1, PGM2↑ENO1 and PGM2, ↑glycolysis[33]
GLUT1, LDHA, HK2↑GLUT1, LDHA and HK2, ↑glycolysis[37]
CypA↑CypA, ↓apoptosis, ↑cells proliferation, migration and invasion[38]
MiR-21↑MiR-21, ↓apoptosis, ↑cells proliferation[40]
MT2-MMP↑MT2-MMP, ↓apoptosis, ↑cells proliferation and invasion[42]
MTA2↑MTA2, ↓E-cadherin, ↑EMT, cells migration and invasion[49]
Twist↑Twist, ↓ E-cadherin, ↑EMT and cells proliferation[50]
Snail↑Snail, ↓E-cadherin, ↑N-cadherin, ↑EMT, cells migration and invasion[51]
LncRNA-BX111↑LncRNA-BX111, ↑ZEB1, MMP-2, ↓E-cadherin, ↑EMT, ↑tumor growth and metastasis[52]
CD133↑CD133, ↑tumor stem cell properties, ↑cells migration and invasion[56]
RER1↑RER1, ↑N-cadherin, Vimentin and Snail, ↓E-cadherin, ↑Sox2, Bmi1, Lin28 and Nanog, ↑EMT and cancer stem cell-like properties[58]
ATG5, Beclin1↑ATG5 and Beclin1, ↑autophagy and cancer stem cell-like properties[59]
ABCG2↑ABCG2, ↑ chemoresistance[64]
NF-κB↑NF-κB, ↓E-cadherin, ↑N-cadherin, Vimentin, Snail, Twist, ↑EMT and chemoresistance[65]
CXCR4↑CXCR4, ↑chemoresistance[66]
IL-37↓IL-37, ↑chemoresistance[68]
VEGF-A↑VEGF-A, ↑angiogenesis, ↑tumor growth[73]
STAT3, VEGF-A↑VEGF-A and STAT3, ↑angiogenesis, ↑tumor growth[75]
CHC, VEGF-A↑CHC and VEGF-A, ↑angiogenesis, ↑tumor growth[77]
VEGF, MMP-2, MMP-9↑VEGF, MMP-2 and MMP-9, ↑angiogenesis, ↑tumor growth[78]
ADAM10↑AMAD10, ↓mMICA, ↑sMICA, ↓NKG2D, ↓NK cells cytotoxicity, ↑immune evasion[82]
CCL2↑CCL2, ↑α-SMA, ↑desmoplasia[85]
SHH↑SHH, ↑HH signaling, ↑ collagen Ι and fibronectin, ↑desmoplasia[84, 86]
  1. ↑, promote; ↓, inhibit; KRAS, V-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog; FOXC2, forkhead box C2; STIM1, stromal interaction molecule 1; PKM2, M2 isoform of pyruvate kinase; ENO1, enolase 1; PGM2, phosphoglucomutase-2; GLUT1, glucose transporter type 1; LDHA, lactate dehydrogenase A; HK2, hexokinase 2; CypA, cyclophilin A; MT2-MMP, membrane type-2 matrix metalloproteinase; MTA2, metastasis-associated protein 2; EMT, epithelial mesenchymal transition; ZEB1, zinc finger E-box-binding protein 1; MMP-2, matrix metalloproteinase 2; RER1, retention in endoplasmic reticulum 1; ATG5, autophagy related 5; ABCG2, ATP-binding cassette subfamily G member 2; CXCR4, chemokine receptor 4; VEGF-A, vascular endothelial growth factor A; STAT3, signal transducer and activator of transcription 3; CHC, clathrin heavy chain; MMP-9: matrix metalloproteinase 9; ADAM10, a disintegrin and metalloproteinase domain 10; mMICA, membrane major histocompatibility complex class I molecular associated proteins A; sMICA, soluble major histocompatibility complex class I molecular associated proteins A; NKG2D, natural killer group 2 member D; CCL2, chemical chemokine 2; α-SMA, α-smooth muscle actin; SHH, sonic hedgehog; HH, hedgehog