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Fig. 5 | Cancer Cell International

Fig. 5

From: Long non-coding RNA NORAD exhaustion represses prostate cancer progression through inhibiting TRIP13 expression via competitively binding to miR-495-3p

Fig. 5

Reduced miR-495-3p expression mitigated NORAD knockdown-mediated influence on cell proliferation, apoptosis, migration and invasion in PCa cells. a QRT-PCR was conducted for the evaluation of the expression of miR-495-3p in 22Rv1 and LNCaP cells. aj 22Rv1 and LNCaP cells were transfected with si-NORAD, si-NC, si-NORAD + anti-miR-NC, or si-NORAD + anti-miR-495-3p. b, c The proliferation of 22Rv1 and LNCaP cells was analyzed with MTT assay. d Flow cytometry assay was executed for the assessment of the apoptosis of 22Rv1 and LNCaP cells. e, f Teanswell assay was carried out for the detection of cell migration and invasion in 22Rv1 and LNCaP cells. gj The levels of Bax, Cleaved-casp-3, and Bcl-2 in 22Rv1 and LNCaP cells were assessed with western blot analysis. The experiments were performed in triplicate. *P < 0.05, **P < 0.01, and ***P < 0.001

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