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Fig. 2 | Cancer Cell International

Fig. 2

From: A newly identified lncRNA H1FX-AS1 targets DACT1 to inhibit cervical cancer via sponging miR-324-3p

Fig. 2Fig. 2

Over-expression of H1FX-AS1 inhibited proliferation, migration and invasion,while induced apoptosis in CC cells both in vivo and in vitro. To investigate the influence of H1FX-AS1 expression in CC development, H1FX-AS1 was over-expressed in SiHa and HeLa cells (the two tested cell lines showing the lowest H1FX-AS1 expression), when RT-qPCR analysis confirmed that H1FX-AS1 was successfully over-expressed in both the SiHa and HeLa cells a, the following phenotypes were further estimated in the SiHa and HeLa cells over-expressed H1FX-AS1 (OE-H1FX-AS1): b cell viability, c clone formation ability (images: upper panel; quantification: lower panel), d cell migration(images: upper panel; quantification: lower panel), e cell invasion(images: left panel; quantification: right panel), f apoptosis (images: upper panel; quantification: lower panel), g apoptosis-related proteins (images: upper panel; quantification: lower panel). OE-H1FX-AS1 in both the SiHa and HeLa cells inhibited the xenograft tumor growth: h growth curve (tumor volume) analysis of the xenograft tumors with H1FX-AS1 over-expressed or the control vector transfected SiHa or HeLa cells; i the average tumor weights between the over-expressed or the control vector transfected SiHa or HeLa cell groups. **p < 0.01

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