USP4 function and multifaceted roles in cancer: a possible and potential therapeutic target

Table 2 The substrates and mechanisms of USP4 in cancers mentioned in this review

Authors, year	Type of cancer	In vivo or in vitro study	USP4 expression	Deubiquitinated targets	Effects to the deubiquitinated targets	Regulated tumor biological behaviors	Refs.
Xiao et al., 2012	Lung cancer	In vitro	Down	TRAF2 and TRAF6	Inactivation	Cell migration inhibition	[42]
Mehić et al., 2017	Lung cancer	In vitro	Down	HAS2	Inactivation	–	[88]
Hwang et al., 2016	Lung cancer	In vitro and in vivo	Up	β-catenin	Stabilization	Cell migration and invasion enhancement; Brain metastasis of lung cancer	[90]
Zhang et al., 2012	Breast cancer	In vitro	Up	TβRI	Stabilization	Cell migration enhancement	[27]
Wang et al., 2018	Breast cancer	In vitro and in vivo	Up	HDAC2	Stabilization	Cell proliferation and tumor growth enhancement	[92]
Li et al., 2016	Breast cancer	In vitro and in vivo	Down	PCD4	Stabilization	Cell proliferation and tumor growth inhibition	[94]
Qiu et al., 2018	Liver cancer	In vitro and in vivo	Up	TβRI	Stabilization	Tumor metastasis enhancement	[97]
Li et al., 2018	Liver cancer	In vitro and in vivo	Up	CypA	Stabilization	Tumor growth and metastasis enhancement	[98]
Yun et al., 2015	Colorectal cancer	In vitro	Up	β-catenin	Stabilization	Cell migration and invasion enhancement	[37]
Xing et al., 2015	Colorectal cancer	In vitro and in vivo	Up	PRL-3	Stabilization	Tumor growth and metastasis enhancement	[101]
Hou et al., 2013	Head and neck squamous cell carcinoma	In vitro	Up	RIP1	Inactivation	TNFα-induced cell apoptosis enhancement	[105]

ISSN: 1475-2867