Skip to main content

Table 2 The substrates and mechanisms of USP4 in cancers mentioned in this review

From: USP4 function and multifaceted roles in cancer: a possible and potential therapeutic target

Authors, year Type of cancer In vivo or in vitro study USP4 expression Deubiquitinated targets Effects to the deubiquitinated targets Regulated tumor biological behaviors Refs.
Xiao et al., 2012 Lung cancer In vitro Down TRAF2 and TRAF6 Inactivation Cell migration inhibition [42]
Mehić et al., 2017 Lung cancer In vitro Down HAS2 Inactivation [88]
Hwang et al., 2016 Lung cancer In vitro and in vivo Up β-catenin Stabilization Cell migration and invasion enhancement; Brain metastasis of lung cancer [90]
Zhang et al., 2012 Breast cancer In vitro Up TβRI Stabilization Cell migration enhancement [27]
Wang et al., 2018 Breast cancer In vitro and in vivo Up HDAC2 Stabilization Cell proliferation and tumor growth enhancement [92]
Li et al., 2016 Breast cancer In vitro and in vivo Down PCD4 Stabilization Cell proliferation and tumor growth inhibition [94]
Qiu et al., 2018 Liver cancer In vitro and in vivo Up TβRI Stabilization Tumor metastasis enhancement [97]
Li et al., 2018 Liver cancer In vitro and in vivo Up CypA Stabilization Tumor growth and metastasis enhancement [98]
Yun et al., 2015 Colorectal cancer In vitro Up β-catenin Stabilization Cell migration and invasion enhancement [37]
Xing et al., 2015 Colorectal cancer In vitro and in vivo Up PRL-3 Stabilization Tumor growth and metastasis enhancement [101]
Hou et al., 2013 Head and neck squamous cell carcinoma In vitro Up RIP1 Inactivation TNFα-induced cell apoptosis enhancement [105]