Fig. 6

Association between the SNORS with clinicopathological characteristics and molecular subtypes. a Cluster heat map showed the relative levels of candidate snoRNAs which were stratified by SNORS in the TCGA-BLCA cohort. Yellow means upregulation while blue means downregulation. b–g Differences in SNORS between different clinicopathological characteristics and clinical outcome in TCGA-BLCA cohort. The upper and lower ends of the boxes represented interquartile range of values. The lines in the boxes represented median value. Student t tests or one-way Anova tests were used to compare the statistical difference between primary therapy outcome (b), additional treatment outcome (c), pathological tumour stage (d), neoplasm cancer statue (e), new tumour event (f), and histology subtype (g). h Alluvial diagram showing the dynamic changes of SNORS, indicated molecular subtypes and vital status in TCGA-BLCA cohort. i–n Differences in SNORS between different molecular subtypes in TCGA-BLCA cohort. The upper and lower ends of the boxes represented interquartile range of values. The lines in the boxes represented median value. Student t tests and one-way Anova tests were used to compare the statistical difference between Lund1 (i), Lund2 (j), CC (k), TCGAcluster (l), MDA (m), and UNC (n) molecular classification systems