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Fig. 4 | Cancer Cell International

Fig. 4

From: The MRTF-A/miR-155/SOX1 pathway mediates gastric cancer migration and invasion

Fig. 4

MRTF-A was crucial for miR-155 activation induced by Wnt signaling (a, c) MRTF-A and miR-155 RNA levels were concurrently upregulated in LiCl-treated SGC-7901cells. b MRTF-A protein expression was upregulated in LiCl-treated MCF-7 cells. ac Cells were treated with 2.5 mM LiCl for 24 h. Depletion of MRTF-A abolished the LiCl-induced upregulation of miR-155 in SGC-7901 cells. d, f MRTF-A and miR-155 RNA levels were concurrently increased in Wnt3a-treated SGC-7901 cells. e MRTF-A protein expression was concurrently induced in Wnt3a-treated SGC-7901 cells. dg Cells were treated with 10 μM Wnt3a for 24 h. Depletion of MRTF-A abolished the Wnt3a-induced upregulation of miR-155 in SGC-7901 cells (g, i) Knockout of β-catenin concurrently decreased MRTF-A and miR-155 expression in SGC-7901 cells. h MRTF-A protein expression was decreased in si-β-catenin-treated SGC-7901 cells. Data are shown as the mean ± S.E.M, based on three to six independent experiments. **, p < 0.01

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