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Fig. 4 | Cancer Cell International

Fig. 4

From: Gamma synuclein is a novel nicotine responsive protein in oral cancer malignancy

Fig. 4

The α7-nAChR/AKT pathway is involved in nicotine-induced SNCG expression. a OEC-M1 cells were pretreated with or without 40 μM PI3K/AKT inhibitor then treated with or without 1 μM nicotine for 24 h. Total proteins were harvested and subjected to Western blot analysis of P-AKT, total AKT, and SNCG expression. GAPDH was also detected as loading control. b OEC-M1 cells with or without α7 nAChR knockdown were plated in cell culture dishes and treated with or without 1 μM nicotine for 24 h. The cell lysates were harvested and subjected to Western blot analysis of P-AKT, total AKT, and SNCG expression

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