Skip to main content

Table 1 GO and KEGG pathway enrichment analysis of DEGs in KIRC samples

From: Identifying the novel key genes in renal cell carcinoma by bioinformatics analysis and cell experiments

Term/pathway ID

Description

Count in gene set

P-value

BP

 GO:0019752

Carboxylic acid metabolic process

45

1.07E−16

 GO:0006082

Organic acid metabolic process

47

1.23E−16

 GO:0043436

Oxoacid metabolic process

45

1.33E−16

 GO:0044282

Small molecule catabolic process

25

6.84E−12

 GO:0001822

Kidney development

22

1.91E−11

 GO:0072001

Renal system development

22

5.72E−11

 GO:0055114

Oxidation–reduction process

40

8.91E−11

 GO:0016054

Organic acid catabolic process

19

3.42E−10

 GO:0001655

Urogenital system development

22

5.53E−10

 GO:0006811

Ion transport

48

8.49E−10

CC

 GO:0070062

Extracellular exosome

101

9.00E−25

 GO:1903561

Extracellular vesicle

101

1.34E−24

 GO:0043230

Extracellular organelle

101

1.38E−24

 GO:0031988

Membrane-bounded vesicle

107

7.12E−20

 GO:0044421

Extracellular region part

108

5.23E−18

 GO:0005576

Extracellular region

113

1.48E−14

 GO:0045177

Apical part of cell

26

1.04E−11

 GO:0016323

Basolateral plasma membrane

20

2.35E−11

 GO:0016324

Apical plasma membrane

23

4.15E−11

 GO:0098590

Plasma membrane region

39

3.45E−10

MF

 GO:0048037

Cofactor binding

20

2.23E−09

 GO:0050662

Coenzyme binding

14

7.50E−07

 GO:0015291

Secondary active transmembrane transporter activity

15

1.92E−06

 GO:0008509

Anion transmembrane transporter activity

14

2.26E−06

 GO:0022804

Active transmembrane transporter activity

18

5.05E−06

 GO:0016614

Oxidoreductase activity, acting on CH–OH group of donors

11

1.05E−05

 GO:1901681

Sulfur compound binding

13

4.69E−05

 GO:0015103

Inorganic anion transmembrane transporter activity

10

5.01E−05

 GO:0016709

Oxidoreductase activity, with incorporation or reduction of molecular oxygen

6

2.11E−04

 GO:0042802

Identical protein binding

34

2.45E−04

KEGG

 hsa01100

Metabolic pathways

48

3.79E−09

 hsa01130

Biosynthesis of antibiotics

18

6.50E−08

 hsa01200

Carbon metabolism

12

2.45E−06

 hsa04960

Aldosterone-regulated sodium reabsorption

6

4.38E−04

 hsa00010

Glycolysis/Gluconeogenesis

7

8.33E−04

 hsa00280

Valine, leucine and isoleucine degradation

6

1.05E−03

 hsa00020

Citrate cycle (TCA cycle)

5

1.45E−03

 hsa00260

Glycine, serine and threonine metabolism

5

3.88E−03

 hsa04610

Complement and coagulation cascades

6

5.74E−03

 hsa04966

Collecting duct acid secretion

4

9.94E−03

  1. BP, biological process; CC, cellular component; MF, molecular function