Table 3 Functional roles of 11 hub genes with betweenness degrees ≥ 10
No. | Gene symbol | Full name | Function |
|---|---|---|---|
1 | ANK2 | Ankyrin 2 | Attaches integral membrane proteins to cytoskeletal elements.Also binds to cytoskeletal proteins. Plays a role in endocytosis and intracellular protein transport |
2 | SUCLG1 | Succinate-CoA Ligase Alpha Subunit | Succinyl-CoA synthetase functions in the citric acid cycle, coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP |
3 | GLDC | Glycine Decarboxylase | The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) |
4 | SLC12A1 | Solute Carrier Family 12 Member 1 | Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume |
5 | PIPOX | Pipecolic Acid And Sarcosine Oxidase | Metabolizes sarcosine, L-pipecolic acid and l-proline |
6 | KNG1 | Kininogen 1 | Kininogens 1 is inhibitors of thiol proteases; plays an important role in blood coagulation; inhibits the thrombin- and plasmin-induced aggregation of thrombocytes |
7 | SLC9A2 | Solute Carrier Family 9 Member A2 | Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions |
8 | PCK2 | Phosphoenolpyruvate Carboxykinase 2 | Catalyzes the conversion of oxaloacetate to phosphoenolpyruvate |
9 | XPNPEP2 | X-Prolyl Aminopeptidase 2 | Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides. May play a role in the metabolism of the vasodilator bradykinin |
10 | ATP1A1 | ATPase Na+/K+ Transporting Subunit Alpha 1 | This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients |
11 | PDHA1 | Pyruvate Dehydrogenase E1 Alpha 1 Subunit | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle. |