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Table 1 The proteins observed to be differentially expressed by iTRAQ analysis in HepG2 cells: control vs FASN knockdown

From: Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis

N Accession Gene symbol Name Peptides (95%) 114:118 PVal 114:118 117:121 PVal 117:121
1 sp|P35579|MYH9_HUMAN MYH9 Myosin-9 1552 7.733154 1.60E−43 7.994438 0
2 sp|P35580|MYH10_HUMAN MYH10 Myosin-10 467 4.294018 5.51E−30 4.44725 2.10E−29
3 sp|P49327|FAS_HUMAN FASN Fatty acid synthase 259 4.910331 1.01E−22 5.591387 4.95E−26
4 sp|Q15149|PLEC_HUMAN PLEC Plectin 220 1.397022 2.65E−22 1.404792 2.59E−18
5 sp|Q562R1|ACTBL_HUMAN ACTBL2 Beta-actin-like protein 2 199 2.428919 0.272743016 2.635309 0.104194321
6 sp|Q7Z406|MYH14_HUMAN MYH14 Myosin-14 176 5.295912 0.297084481 5.43472 0.193289608
7 tr|Q562M3|Q562M3_HUMAN ACT Actin-like protein (Fragment) 166 9.05212 0.372466028 9.267368 0.316949397
8 sp|Q13813|SPTN1_HUMAN SPTAN1 Spectrin alpha chain, non-erythrocytic 1 156 1.911921 1.78E−30 2.049046 1.18E−29
9 sp|Q01082|SPTB2_HUMAN SPTBN1 Spectrin beta chain, non-erythrocytic 1 129 1.72504 7.48E−17 1.836707 2.02E−19
10 sp|O43707|ACTN4_HUMAN ACTN4 Alpha-actinin-4 127 2.037938 4.27E−11 2.040798 1.32E−08
11 tr|A0A024QZ63|A0A024QZ63_HUMAN hCG_27198 HCG27198, isoform CRA_c 96 2.793359 1.11E−17 2.821251 1.73E−17
12 tr|E9PDF6|E9PDF6_HUMAN MYO1B Unconventional myosin-Ib 93 3.796812 3.36E−16 3.796442 2.41E−14
13 sp|P12814|ACTN1_HUMAN ACTN1 Alpha-actinin-1 89 1.795801 1.21E−07 1.827206 4.69E−10
14 tr|E9PMS6|E9PMS6_HUMAN LMO7 LIM domain only protein 7 80 5.813494 0.00171887 5.941699 0.000842874
15 sp|O00159|MYO1C_HUMAN MYO1C Unconventional myosin-Ic 79 3.791151 4.93E−15 4.197793 2.33E−16
16 sp|P05187|PPB1_HUMAN ALPP Alkaline phosphatase, placental type 77 3.799343 2.03E−07 3.740495 4.97E−06
17 tr|H6VRG3|H6VRG3_HUMAN KRT1 Keratin 1 74 1.389211 4.01E−05 1.443922 9.06E−05
18 tr|Q6IBG1|Q6IBG1_HUMAN MYL9 MYL9 protein 72 5.451808 0.100002006 5.182482 0.143713728
19 tr|E7ERU0|E7ERU0_HUMAN DST Dystonin 65 1.370127 5.16E−06 1.3949 0.000138176
20 tr|A0A024RAC0|A0A024RAC0_HUMAN LUZP1 Leucine zipper protein 1, isoform CRA_a 55 2.472267 2.43E−09 2.691021 1.41E−10
21 sp|Q6WCQ1|MPRIP_HUMAN MPRIP Myosin phosphatase Rho-interacting protein 55 3.734554 2.18E−06 4.085938 2.84E−05
22 sp|P07951|TPM2_HUMAN TPM2 Tropomyosin beta chain 53 2.661941 0.144164726 2.68936 0.13973473
23 tr|B2RMV2|B2RMV2_HUMAN CYTSA CYTSA protein 49 2.508032 3.31E−07 2.754671 4.77E−08
24 sp|Q14126|DSG2_HUMAN DSG2 Desmoglein-2 48 1.883534 1.69E−06 2.019478 1.55E−07
25 sp|P13645|K1C10_HUMAN KRT10 Keratin, type I cytoskeletal 10 48 1.602823 2.68E−05 1.690192 0.000321689
26 sp|Q13045|FLII_HUMAN FLII Protein flightless-1 homolog 47 2.873587 2.94E−05 2.817423 0.000103526
27 sp|P52907|CAZA1_HUMAN CAPZA1 F-actin-capping protein subunit alpha-1 46 2.671351 7.88E−05 2.75277 4.64E−05
28 sp|Q16658|FSCN1_HUMAN FSCN1 Fascin 43 1.463882 6.24E−06 1.533627 8.91E−05
29 sp|Q9NYL9|TMOD3_HUMAN TMOD3 Tropomodulin-3 43 3.386163 1.76E−05 3.824799 4.70E−06
30 tr|A0A024R1X8|A0A024R1X8_HUMAN JUP Junction plakoglobin, isoform CRA_a 42 1.554556 3.78E−06 1.593763 2.35E−06
31 sp|O95425|SVIL_HUMAN SVIL Supervillin 41 2.602663 0.001037095 2.961881 0.000195296
32 tr|H0YNH8|H0YNH8_HUMAN UACA Uveal autoantigen with coiled-coil domains and ankyrin repeats 39 2.042608 3.15E−09 2.11368 1.46E−08
33 sp|P06753|TPM3_HUMAN TPM3 Tropomyosin alpha-3 chain 39 4.380041   4.116189  
34 sp|P09493|TPM1_HUMAN TPM1 Tropomyosin alpha-1 chain 38 1.762385 0.077036962 1.635907 0.105389036
35 sp|Q16643|DREB_HUMAN DBN1 Drebrin 30 2.311505 9.75E−06 2.453286 4.25E−05
36 sp|Q9P0K7|RAI14_HUMAN RAI14 Ankycorbin 28 2.148152 6.41E−05 2.3614 2.19E−06
37 sp|O15020|SPTN2_HUMAN SPTBN2 Spectrin beta chain, non-erythrocytic 2 28 1.406392 0.009421338 1.503684 0.000358563
38 sp|Q9Y608|LRRF2_HUMAN LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 28 2.300938 5.18E−05 2.352907 3.49E−05
39 sp|P35908|K22E_HUMAN KRT2 Keratin, type II cytoskeletal 2 epidermal 28 1.646153 0.000577865 1.690331 1.07E−05
40 tr|A0A087X0K9|A0A087X0K9_HUMAN TJP1 Tight junction protein ZO-1 27 1.514412 3.06E−05 1.427997 0.000557715
41 tr|Q6IB58|Q6IB58_HUMAN FLOT1 FLOT1 protein 25 1.631902 9.55E−05 1.920704 7.39E−08
42 sp|Q13428|TCOF_HUMAN TCOF1 Treacle protein 24 1.642456 0.000107874 1.874915 2.29E−05
43 sp|Q96N67|DOCK7_HUMAN DOCK7 Dedicator of cytokinesis protein 7 22 1.327668 0.065086178 1.601374 0.008569049
44 sp|Q96FS4|SIPA1_HUMAN SIPA1 Signal-induced proliferation-associated protein 1 21 2.159191 0.000983656 2.413208 0.000588341
45 sp|Q12792|TWF1_HUMAN TWF1 Twinfilin-1 21 1.768837 0.001737681 1.843505 0.000554159
46 sp|P07948|LYN_HUMAN LYN Tyrosine-protein kinase Lyn 21 2.997176   2.528003  
47 sp|Q9NQX4|MYO5C_HUMAN MYO5C Unconventional myosin-Vc 20 1.705114 0.01927116 1.751134 0.003605252
48 sp|Q6NYC8|PPR18_HUMAN PPP1R18 Phostensin 19 2.694653 5.02E−05 2.681495 5.17E−05
49 tr|A2NJV5|A2NJV5_HUMAN IGKV A18 Kappa light chain variable region (Fragment) 19 2.28389 0.240758419 2.556679 0.229388431
50 sp|Q96C19|EFHD2_HUMAN EFHD2 EF-hand domain-containing protein D2 18 2.413872 0.000136473 2.746724 4.88E−05
51 sp|Q8IVT2|MISP_HUMAN MISP Mitotic interactor and substrate of PLK1 17 2.113082 1.34E−06 2.19576 4.56E−07
52 sp|O60237|MYPT2_HUMAN PPP1R12B Protein phosphatase 1 regulatory subunit 12B 17 1.666243 0.01486919 1.897841 0.006569633
53 sp|Q9BY89|K1671_HUMAN KIAA1671 Uncharacterized protein KIAA1671 16 1.389878 0.003938706 1.380789 0.009779588
54 sp|Q8N556|AFAP1_HUMAN AFAP1 Actin filament-associated protein 1 15 1.739136 0.000295575 1.771639 0.001590264
55 sp|P04899|GNAI2_HUMAN GNAI2 Guanine nucleotide-binding protein G(i) subunit alpha-2 15 1.390716 0.050071925 1.580288 0.008337548
56 sp|Q96IZ0|PAWR_HUMAN PAWR PRKC apoptosis WT1 regulator protein 15 2.101999 0.002897741 2.172414 0.00319098
57 sp|Q14651|PLSI_HUMAN PLS1 Plastin-1 15 1.491069 0.366374075 1.739802 0.002665657
58 sp|P08754|GNAI3_HUMAN GNAI3 Guanine nucleotide-binding protein G(k) subunit alpha 14 1.465639 0.173583567 1.466131 0.174515322
59 tr|Q5T6N4|Q5T6N4_HUMAN ABLIM1 Actin-binding LIM protein 1 13 1.546123 0.410703063 1.857376 0.177637875
60 sp|Q96PY5|FMNL2_HUMAN FMNL2 Formin-like protein 2 11 1.317802 0.352339953 1.351134 0.216772318
61 sp|Q6YHK3|CD109_HUMAN CD109 CD109 antigen 11 1.334029 0.081696793 1.348319 0.149591982
62 sp|P62879|GBB2_HUMAN GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 11 1.316142 0.118086331 1.369466 0.071457863
63 sp|P28289|TMOD1_HUMAN TMOD1 Tropomodulin-1 10 1.720154 0.042252187 1.918302 0.008569272
64 sp|O15230|LAMA5_HUMAN LAMA5 Laminin subunit alpha-5 10 1.339791 0.117773414 1.57948 0.062586941
65 tr|Q9NZ23|Q9NZ23_HUMAN YA61 Drug-sensitive protein 1 9 1.441324 0.045518585 1.324137 0.034476336
66 tr|Q53Z63|Q53Z63_HUMAN NT5E 5′-nucleotidase 8 1.411206 0.006373217 1.383428 0.003122543
67 sp|Q96II8|LRCH3_HUMAN LRCH3 Leucine-rich repeat and calponin homology domain-containing protein 3 8 1.706335 0.049031802 1.635396 0.055755418
68 tr|Q8TE01|Q8TE01_HUMAN derp12 DERP12 (Dermal papilla derived protein 12) 7 1.828045 0.010396365 1.854288 0.004546963
69 sp|Q96SB3|NEB2_HUMAN PPP1R9B Neurabin-2 6 1.395569 0.015349443 1.600011 0.003934822
70 tr|E9PR17|E9PR17_HUMAN CD59 CD59 glycoprotein 6 1.85682 0.06617903 1.491637 0.179792181
71 sp|Q9BQI0|AIF1L_HUMAN AIF1L Allograft inflammatory factor 1-like 6 2.31311 0.025139008 2.56662 0.090089194
72 sp|P98179|RBM3_HUMAN RBM3 Putative RNA-binding protein 3 6 2.875242 0.285602093 2.315469 0.405406147
73 sp|Q96MG8|PCMD1_HUMAN PCMTD1 Protein-l-isoaspartate O-methyltransferase domain-containing protein 1 5 1.607658 0.017886819 1.554777 0.019220859
74 sp|P19474|RO52_HUMAN TRIM21 E3 ubiquitin-protein ligase TRIM21 3 2.483759 0.021963865 2.311108 0.095597863
75 sp|O95466|FMNL_HUMAN FMNL1 Formin-like protein 1 3 2.878891 0.403065771 1.972982 0.319309711
76 sp|Q4KMQ1|TPRN_HUMAN TPRN Taperin 3 1.340113 0.33699739 1.311182 0.583454609
77 sp|O95396|MOCS3_HUMAN MOCS3 Adenylyltransferase and sulfurtransferase MOCS3 3 2.160296 0.529036522 2.914927 0.466293573
78 tr|K7ELP0|K7ELP0_HUMAN TPM4 Tropomyosin alpha-4 chain (Fragment) 3 3.685683 0.056339081 4.30786 0.11501646
79 tr|A0A024R2J9|A0A024R2J9_HUMAN TBC1D5 TBC1 domain family, member 5, isoform CRA_b 2 1.3353   1.753758