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Table 1 The proteins observed to be differentially expressed by iTRAQ analysis in HepG2 cells: control vs FASN knockdown

From: Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis

N

Accession

Gene symbol

Name

Peptides (95%)

114:118

PVal 114:118

117:121

PVal 117:121

1

sp|P35579|MYH9_HUMAN

MYH9

Myosin-9

1552

7.733154

1.60E−43

7.994438

0

2

sp|P35580|MYH10_HUMAN

MYH10

Myosin-10

467

4.294018

5.51E−30

4.44725

2.10E−29

3

sp|P49327|FAS_HUMAN

FASN

Fatty acid synthase

259

4.910331

1.01E−22

5.591387

4.95E−26

4

sp|Q15149|PLEC_HUMAN

PLEC

Plectin

220

1.397022

2.65E−22

1.404792

2.59E−18

5

sp|Q562R1|ACTBL_HUMAN

ACTBL2

Beta-actin-like protein 2

199

2.428919

0.272743016

2.635309

0.104194321

6

sp|Q7Z406|MYH14_HUMAN

MYH14

Myosin-14

176

5.295912

0.297084481

5.43472

0.193289608

7

tr|Q562M3|Q562M3_HUMAN

ACT

Actin-like protein (Fragment)

166

9.05212

0.372466028

9.267368

0.316949397

8

sp|Q13813|SPTN1_HUMAN

SPTAN1

Spectrin alpha chain, non-erythrocytic 1

156

1.911921

1.78E−30

2.049046

1.18E−29

9

sp|Q01082|SPTB2_HUMAN

SPTBN1

Spectrin beta chain, non-erythrocytic 1

129

1.72504

7.48E−17

1.836707

2.02E−19

10

sp|O43707|ACTN4_HUMAN

ACTN4

Alpha-actinin-4

127

2.037938

4.27E−11

2.040798

1.32E−08

11

tr|A0A024QZ63|A0A024QZ63_HUMAN

hCG_27198

HCG27198, isoform CRA_c

96

2.793359

1.11E−17

2.821251

1.73E−17

12

tr|E9PDF6|E9PDF6_HUMAN

MYO1B

Unconventional myosin-Ib

93

3.796812

3.36E−16

3.796442

2.41E−14

13

sp|P12814|ACTN1_HUMAN

ACTN1

Alpha-actinin-1

89

1.795801

1.21E−07

1.827206

4.69E−10

14

tr|E9PMS6|E9PMS6_HUMAN

LMO7

LIM domain only protein 7

80

5.813494

0.00171887

5.941699

0.000842874

15

sp|O00159|MYO1C_HUMAN

MYO1C

Unconventional myosin-Ic

79

3.791151

4.93E−15

4.197793

2.33E−16

16

sp|P05187|PPB1_HUMAN

ALPP

Alkaline phosphatase, placental type

77

3.799343

2.03E−07

3.740495

4.97E−06

17

tr|H6VRG3|H6VRG3_HUMAN

KRT1

Keratin 1

74

1.389211

4.01E−05

1.443922

9.06E−05

18

tr|Q6IBG1|Q6IBG1_HUMAN

MYL9

MYL9 protein

72

5.451808

0.100002006

5.182482

0.143713728

19

tr|E7ERU0|E7ERU0_HUMAN

DST

Dystonin

65

1.370127

5.16E−06

1.3949

0.000138176

20

tr|A0A024RAC0|A0A024RAC0_HUMAN

LUZP1

Leucine zipper protein 1, isoform CRA_a

55

2.472267

2.43E−09

2.691021

1.41E−10

21

sp|Q6WCQ1|MPRIP_HUMAN

MPRIP

Myosin phosphatase Rho-interacting protein

55

3.734554

2.18E−06

4.085938

2.84E−05

22

sp|P07951|TPM2_HUMAN

TPM2

Tropomyosin beta chain

53

2.661941

0.144164726

2.68936

0.13973473

23

tr|B2RMV2|B2RMV2_HUMAN

CYTSA

CYTSA protein

49

2.508032

3.31E−07

2.754671

4.77E−08

24

sp|Q14126|DSG2_HUMAN

DSG2

Desmoglein-2

48

1.883534

1.69E−06

2.019478

1.55E−07

25

sp|P13645|K1C10_HUMAN

KRT10

Keratin, type I cytoskeletal 10

48

1.602823

2.68E−05

1.690192

0.000321689

26

sp|Q13045|FLII_HUMAN

FLII

Protein flightless-1 homolog

47

2.873587

2.94E−05

2.817423

0.000103526

27

sp|P52907|CAZA1_HUMAN

CAPZA1

F-actin-capping protein subunit alpha-1

46

2.671351

7.88E−05

2.75277

4.64E−05

28

sp|Q16658|FSCN1_HUMAN

FSCN1

Fascin

43

1.463882

6.24E−06

1.533627

8.91E−05

29

sp|Q9NYL9|TMOD3_HUMAN

TMOD3

Tropomodulin-3

43

3.386163

1.76E−05

3.824799

4.70E−06

30

tr|A0A024R1X8|A0A024R1X8_HUMAN

JUP

Junction plakoglobin, isoform CRA_a

42

1.554556

3.78E−06

1.593763

2.35E−06

31

sp|O95425|SVIL_HUMAN

SVIL

Supervillin

41

2.602663

0.001037095

2.961881

0.000195296

32

tr|H0YNH8|H0YNH8_HUMAN

UACA

Uveal autoantigen with coiled-coil domains and ankyrin repeats

39

2.042608

3.15E−09

2.11368

1.46E−08

33

sp|P06753|TPM3_HUMAN

TPM3

Tropomyosin alpha-3 chain

39

4.380041

 

4.116189

 

34

sp|P09493|TPM1_HUMAN

TPM1

Tropomyosin alpha-1 chain

38

1.762385

0.077036962

1.635907

0.105389036

35

sp|Q16643|DREB_HUMAN

DBN1

Drebrin

30

2.311505

9.75E−06

2.453286

4.25E−05

36

sp|Q9P0K7|RAI14_HUMAN

RAI14

Ankycorbin

28

2.148152

6.41E−05

2.3614

2.19E−06

37

sp|O15020|SPTN2_HUMAN

SPTBN2

Spectrin beta chain, non-erythrocytic 2

28

1.406392

0.009421338

1.503684

0.000358563

38

sp|Q9Y608|LRRF2_HUMAN

LRRFIP2

Leucine-rich repeat flightless-interacting protein 2

28

2.300938

5.18E−05

2.352907

3.49E−05

39

sp|P35908|K22E_HUMAN

KRT2

Keratin, type II cytoskeletal 2 epidermal

28

1.646153

0.000577865

1.690331

1.07E−05

40

tr|A0A087X0K9|A0A087X0K9_HUMAN

TJP1

Tight junction protein ZO-1

27

1.514412

3.06E−05

1.427997

0.000557715

41

tr|Q6IB58|Q6IB58_HUMAN

FLOT1

FLOT1 protein

25

1.631902

9.55E−05

1.920704

7.39E−08

42

sp|Q13428|TCOF_HUMAN

TCOF1

Treacle protein

24

1.642456

0.000107874

1.874915

2.29E−05

43

sp|Q96N67|DOCK7_HUMAN

DOCK7

Dedicator of cytokinesis protein 7

22

1.327668

0.065086178

1.601374

0.008569049

44

sp|Q96FS4|SIPA1_HUMAN

SIPA1

Signal-induced proliferation-associated protein 1

21

2.159191

0.000983656

2.413208

0.000588341

45

sp|Q12792|TWF1_HUMAN

TWF1

Twinfilin-1

21

1.768837

0.001737681

1.843505

0.000554159

46

sp|P07948|LYN_HUMAN

LYN

Tyrosine-protein kinase Lyn

21

2.997176

 

2.528003

 

47

sp|Q9NQX4|MYO5C_HUMAN

MYO5C

Unconventional myosin-Vc

20

1.705114

0.01927116

1.751134

0.003605252

48

sp|Q6NYC8|PPR18_HUMAN

PPP1R18

Phostensin

19

2.694653

5.02E−05

2.681495

5.17E−05

49

tr|A2NJV5|A2NJV5_HUMAN

IGKV A18

Kappa light chain variable region (Fragment)

19

2.28389

0.240758419

2.556679

0.229388431

50

sp|Q96C19|EFHD2_HUMAN

EFHD2

EF-hand domain-containing protein D2

18

2.413872

0.000136473

2.746724

4.88E−05

51

sp|Q8IVT2|MISP_HUMAN

MISP

Mitotic interactor and substrate of PLK1

17

2.113082

1.34E−06

2.19576

4.56E−07

52

sp|O60237|MYPT2_HUMAN

PPP1R12B

Protein phosphatase 1 regulatory subunit 12B

17

1.666243

0.01486919

1.897841

0.006569633

53

sp|Q9BY89|K1671_HUMAN

KIAA1671

Uncharacterized protein KIAA1671

16

1.389878

0.003938706

1.380789

0.009779588

54

sp|Q8N556|AFAP1_HUMAN

AFAP1

Actin filament-associated protein 1

15

1.739136

0.000295575

1.771639

0.001590264

55

sp|P04899|GNAI2_HUMAN

GNAI2

Guanine nucleotide-binding protein G(i) subunit alpha-2

15

1.390716

0.050071925

1.580288

0.008337548

56

sp|Q96IZ0|PAWR_HUMAN

PAWR

PRKC apoptosis WT1 regulator protein

15

2.101999

0.002897741

2.172414

0.00319098

57

sp|Q14651|PLSI_HUMAN

PLS1

Plastin-1

15

1.491069

0.366374075

1.739802

0.002665657

58

sp|P08754|GNAI3_HUMAN

GNAI3

Guanine nucleotide-binding protein G(k) subunit alpha

14

1.465639

0.173583567

1.466131

0.174515322

59

tr|Q5T6N4|Q5T6N4_HUMAN

ABLIM1

Actin-binding LIM protein 1

13

1.546123

0.410703063

1.857376

0.177637875

60

sp|Q96PY5|FMNL2_HUMAN

FMNL2

Formin-like protein 2

11

1.317802

0.352339953

1.351134

0.216772318

61

sp|Q6YHK3|CD109_HUMAN

CD109

CD109 antigen

11

1.334029

0.081696793

1.348319

0.149591982

62

sp|P62879|GBB2_HUMAN

GNB2

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

11

1.316142

0.118086331

1.369466

0.071457863

63

sp|P28289|TMOD1_HUMAN

TMOD1

Tropomodulin-1

10

1.720154

0.042252187

1.918302

0.008569272

64

sp|O15230|LAMA5_HUMAN

LAMA5

Laminin subunit alpha-5

10

1.339791

0.117773414

1.57948

0.062586941

65

tr|Q9NZ23|Q9NZ23_HUMAN

YA61

Drug-sensitive protein 1

9

1.441324

0.045518585

1.324137

0.034476336

66

tr|Q53Z63|Q53Z63_HUMAN

NT5E

5′-nucleotidase

8

1.411206

0.006373217

1.383428

0.003122543

67

sp|Q96II8|LRCH3_HUMAN

LRCH3

Leucine-rich repeat and calponin homology domain-containing protein 3

8

1.706335

0.049031802

1.635396

0.055755418

68

tr|Q8TE01|Q8TE01_HUMAN

derp12

DERP12 (Dermal papilla derived protein 12)

7

1.828045

0.010396365

1.854288

0.004546963

69

sp|Q96SB3|NEB2_HUMAN

PPP1R9B

Neurabin-2

6

1.395569

0.015349443

1.600011

0.003934822

70

tr|E9PR17|E9PR17_HUMAN

CD59

CD59 glycoprotein

6

1.85682

0.06617903

1.491637

0.179792181

71

sp|Q9BQI0|AIF1L_HUMAN

AIF1L

Allograft inflammatory factor 1-like

6

2.31311

0.025139008

2.56662

0.090089194

72

sp|P98179|RBM3_HUMAN

RBM3

Putative RNA-binding protein 3

6

2.875242

0.285602093

2.315469

0.405406147

73

sp|Q96MG8|PCMD1_HUMAN

PCMTD1

Protein-l-isoaspartate O-methyltransferase domain-containing protein 1

5

1.607658

0.017886819

1.554777

0.019220859

74

sp|P19474|RO52_HUMAN

TRIM21

E3 ubiquitin-protein ligase TRIM21

3

2.483759

0.021963865

2.311108

0.095597863

75

sp|O95466|FMNL_HUMAN

FMNL1

Formin-like protein 1

3

2.878891

0.403065771

1.972982

0.319309711

76

sp|Q4KMQ1|TPRN_HUMAN

TPRN

Taperin

3

1.340113

0.33699739

1.311182

0.583454609

77

sp|O95396|MOCS3_HUMAN

MOCS3

Adenylyltransferase and sulfurtransferase MOCS3

3

2.160296

0.529036522

2.914927

0.466293573

78

tr|K7ELP0|K7ELP0_HUMAN

TPM4

Tropomyosin alpha-4 chain (Fragment)

3

3.685683

0.056339081

4.30786

0.11501646

79

tr|A0A024R2J9|A0A024R2J9_HUMAN

TBC1D5

TBC1 domain family, member 5, isoform CRA_b

2

1.3353

 

1.753758

 
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Cancer Cell International

ISSN: 1475-2867

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