Table 1 LncRNAs involved in Wnt signaling in CRC
LncRNA | Targeted Wnt pathway | Effects |
|---|---|---|
CCAT1-S CARLo-5 | TCF4 expression through up-regulation of the SNPrs6983267 | Poor prognosis and low survival rate in CRCs |
CCAT-1-L | Interacts with the chromatin modeler CTCF and MYC expression | Growth and differentiation of CRC |
CCAT-2 | Regulates the TCF7L2 expression through up-regulation of the SNPs | Poor prognosis and low survival rate in CRCs and promotes metastasis and proliferation |
CASC11 | Activates the expression of Beta-Catenin and modulates the expression of MYC gene through SNP rs16902359 | Elevates tumorigenesis and metastases of primary tumors to lymph-nodes in CRC |
PVT1 | Acts as scaffold RNA site that covers Threonine residue 58 and controls a range of miRNAs such as the miR-1204, miR-1205, miR-1206, miR-1207-5p, miR-1207-3p and miR-1208 | Poor prognosis and low survival rate in CRCs and promotes metastasis and proliferation |
Lnc34a | Regulates the expression of miRNA-34a which acts on TCF7L2 and beta-catenin and Notch signaling | Asymmetric growth of CRC stem cell |
RBM5-AS1 | Beta-Catenin and SGK1, YAP1 and MYC via TCF7L2 transcription factor | Growth and proliferation of CRC stem cells in vivo and in vitro |
ASCL2 | Beta-catenin production and interaction with TCF7L2 | Growth and stemness of CRC stem cells and intestinal cells |
WiNTRLINC1 | Beta-Catenin and ASCL2 expression | Poor prognosis and low survival rate in CRCs and promotes metastasis |
PCAT1 | Regulates the expression of LGR5 gene and Wnt signaling to promote the expression of MYC | Poor prognosis and low survival rate in CRCs and promotes metastasis |
lncRNA H19 | Regulates the expression of MYC and beta-catenin through CDK8 production | Growth and proliferation of CRC |
CCAL | β-catenin/TCF7L2 and multidrug resistance gene 1 (MDR-1) and modulates the expression of AP2α | Poor survival, devastating metastasis and resistance to adjuvant chemotherapy in CRC |