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Table 2 Univariate and multivariate analysis of clinical variables and ATP1As for OS

From: Comprehensive analysis of the expression of sodium/potassium-ATPase α subunits and prognosis of ovarian serous cystadenocarcinoma

Characteristics Univariate analysis Multivariate analysis
Hazard ratio (95% CI) p-value Hazard ratio (95% CI) p-value
FIGO stage (stage I–II vs. stage III–IV) 2.085 (0.925–4.699) 0.076 1.638 (0.392–6.854) 0.499
Histologic grade (G1–2 vs. G3–4) 1.194 (0.797–1.789) 0.389   
Primary therapy outcome (PR-CR vs. SD-PD) 0.306 (0.207–0.451) < 0.001 0.247 (0.161–0.38) < 0.001
Age (< 60 vs. ≥ 60) 1.329 (1.025–1.722) 0.032 1.305 (0.948–1.794) 0.102
Tumor residual (NRD vs. RD) 2.302 (1.479–3.583) < 0.001 2.149 (1.285–3.594) 0.004
Lymphatic invasion (no vs. yes) 1.422 (0.839–2.411) 0.191   
Venous invasion (no vs. yes) 0.905 (0.487–1.683) 0.753   
Anatomic subdivision (unilateral vs. bilateral) 1.041 (0.768–1.41) 0.798   
TP53 mutation (no vs. yes) 0.692 (0.423–1.132) 0.143   
BRCA mutation (no vs. yes) 0.65 (0.361–1.171) 0.152   
ATP1A1 (low vs. high) 1.148 (0.885–1.49) 0.298   
ATP1A2 (low vs. high) 1.257 (0.968–1.632) 0.086 1.564 (1.134–2.157) 0.006
ATP1A3 (low vs. high) 1.6 (1.232–2.077) < 0.001 1.932 (1.397–2.673) < 0.001
ATP1A4 (low vs. high) 0.748 (0.575–0.972) 0.03 0.555 (0.4–0.771) < 0.001