Linc00473 potentiates cholangiocarcinoma progression by modulation of DDX5 expression via miR-506 regulation

Table 2 Univariate and multivariate analyses for overall survival of CCA patients

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	p-value	HR	95% CI	p-value
Age (years) < 60 vs. ≥ 60	0.647	0.371–.127	0.124
Gender Male vs. female	1.500	0.831–2.707	0.178
Tumor location Extrahepatic vs. intrahepatic	1.118	0.619–2.021	0.712
Differentiation grade Poor/undifferentiated vs. well/moderate	0.947	0.471–1.904	0.878
HBV infection Positive vs. negative	0.740	0.320–1.711	0.481
Serum CEA level (ng/ml) ≤ 5 vs. > 5	1.200	0.568–2.534	0.633
Serum CA19-9 level (µ/ml) ≤ 37 vs. > 37	1.394	0.645–3.312	0.398
Tumor size (cm) < 3 vs. ≥ 3	0.898	0.514–1.571	0.707
TNM stage I–II vs. III–IV	1.741	1.084–2.686	0.037	1.463	0.958–1.832	0.071
Lymph node invasion Positive vs. negative	1.543	1297–2.211	0.049	2.485	0.914–3.295	0.563
linc000473 expression High vs. low	2.365	1.340–4.173	0.013	2.352	1.302–4.876	0.001

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