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Fig. 2 | Cancer Cell International

Fig. 2

From: circ_0084927 promotes cervical carcinogenesis by sponging miR-1179 that suppresses CDK2, a cell cycle-related gene

Fig. 2

The identification of mRNA and miRNA. a The DEGs involved in the three GSEA datasets were screened out, and 14 of them went through STRING analysis (b). Among the genes in the STRING network, we noticed that CDK2 had been studied thoroughly in cervical cancer; however, its networking with circRNAs had been studied conclusively. Thus, CDK2 was chosen as our gene of interest in this study. c GEPIA algorithm produced the relative expression of CDK2 in cervical squamous cancer (CESC). Num = number. T = tumor, N = healthy normal. d The identification of miRNA can be sponged by circ_0084927 and target CDK2 mRNA. The downstream miRNAs of circ_0084927 was predicted by circular RNA interactome (https://circinteractome.nia.nih.gov/), while the upstream miRNAs of CDK2 mRNA were predicted by TargetScan Human 7.2. Finally, miR-1179 was identified. e The relative expression of miR-1179 in our collected tissue samples

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