Fig. 3

circ_0084927 directly targeted miR-1179. a The scheme showed that circ_0084927 interacted with the 3′UTR oligonucleotide sequence of miR-1179. The binding relationship was predicted by circular RNA interactome. b The potential binding between circ_0084927 and miR-1179 was validated by dual-luciferase reporter assay. circ_0084927 mutant or circ_0084927 wild-type plasmids containing fluorescein and miR-1179 mimic were co-transfected into HeLa cells and C-33A cells. **P < 0.01, compared with the NC group. c The interaction between circ_0084927 and miR-1179 was measured by RIP analysis. IgG was the negative control for AGO2, while NC was the negative control for miR-1179 mimic. **P < 0.01, compared with NC group. d The expression of miR-1179 in cervical cancer tissues was tested by qRT-PCR with U6 as an internal control. A negative correlation relationship between circ_0084927 and miR-1179 expression was identified by spearman correlation analysis. e The expression of miR-1179 in cell lines. *P < 0.05, **P < 0.01, compared with the HcerEpic cell line, which is the control cell line. b–e The data were in the form of mean ± SD of three experiments