Fig. 5
From: EO771, the first luminal B mammary cancer cell line from C57BL/6 mice
The EO771 phenotype and their sensitivity to tamoxifen. EO771 cells express ERβ, PR and HER2. In presence of estrogens, ERβ are translocated to the nucleus where they bind to the estrogen response elements (ERE) inducing transduction of target genes. Anti-estrogen treatments, such as tamoxifen, block this effect. On the contrary, tamoxifen induces the activation of p38 and JNK pathway, leading to apoptosis, but also increases the MMP3 level