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Fig. 6 | Cancer Cell International

Fig. 6

From: LncRNA HOTAIR induces sunitinib resistance in renal cancer by acting as a competing endogenous RNA to regulate autophagy of renal cells

Fig. 6

Effect of HOTAIR on sunitinib resistance of nude mouse xenografts. The nude mice were injected with 786-O-R or ACHN-R cells to establish xenograft models, followed by sunitinib treatment and sh-HOTAIR (sh-NC) injection. Tumor size was weekly recorded. Injection with sh-HOTAIR amplified the inhibitory effect of sunitinib on RC (a). qRT-PCR, Western blot, and immunohistochemistry were adopted to assay the expressions of HOTAIR (b), miR-17-5p (c), Beclin1 (d, e), LC3-II/LC3-I (f), p62 (f), and Ki67 (g). Injection with sh-HOTAIR heightened levels of miR-17-5p and p62, restrained HOTAIR expression, as well as decreased Beclin1 and LC3-II/LC3-I. Additionally, knockdown of HOTAIR in RC nude mice inhibited proliferation of tumor; *P < 0.05, **P < 0.01, compared to suni + sh-NC group or 786-O-R + suni + sh-NC or ACHN-R + suni + sh-NC; RC, renal cancer

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Cancer Cell International

ISSN: 1475-2867

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