Fig. 4

MiR-106a recovered the inhibitory effect of circ-ITCH on ovarian cancer cell progression. a The level of miR-106a in A2780 and OVCAR3 cells transfected with pcDNA, circ-ITCH, circ-ITCH + miR-con or si-circ-ITCH + miR-106a was measured by qRT-PCR. b The proliferation of A2780 and OVCAR3 cells was assessed by CCK-8 assay. c The invasion of A2780 and OVCAR3 cells was measured by Transwell assay with Matrigel. d, f Glucose consumption, lactate production and ATP level in A2780 and OVCAR3 cells were examined by glucose, lactate and ATP assay kits, respectively. g The apoptosis of A2780 and OVCAR3 cells was analyzed by Flow cytometry. *P < 0.05, **P < 0.01, ***P < 0.001