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Fig. 2 | Cancer Cell International

Fig. 2

From: Long non-coding RNA KCNQ1OT1 up-regulates CTNND1 by sponging miR-329-3p to induce the proliferation, migration, invasion, and inhibit apoptosis of colorectal cancer cells

Fig. 2

Knockdown of KCNQ1OT1 suppressed CRC cell proliferation, migration, invasion and promoted cell apoptosis. a The expression of KCNQ1OT1 was detected by qRT-PCR in SW480 and LS1034 cells by transfecting with specific siRNAs. b, c Proliferative ability of SW480 and LS1034 cells transfected with si-KCNQ1OT1#1 or si-KCNQ1OT1#2 was examined by MTT assay. d, e The cell cycle analysis of SW480 and LS1034 cells was detected by flow cytometry. f The cellular apoptosis of SW480 and LS1034 cells was tested by flow cytometry. g, h The migration and invasion of SW480 and LS1034 cells after transfected with si-KCNQ1OT1 were revealed by Transwell assays. i, j The protein levels of EMT markers (E-cadherin, MMP9), CyclinD1, apoptosis-associated proteins (Bcl-2, Cleaved-casp-3) were measured by western blot assays. *P < 0.05, vs. control group

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