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Fig. 5 | Cancer Cell International

Fig. 5

From: Long non-coding RNA KCNQ1OT1 up-regulates CTNND1 by sponging miR-329-3p to induce the proliferation, migration, invasion, and inhibit apoptosis of colorectal cancer cells

Fig. 5

CTNND1 was a direct target gene of miR-329-3p. a The predicted binding sites of miR-329-3p and CTNND1. b, c Thedual-luciferase reporter assay was utilized to determine the luciferase activity of miR-329-3p and CTNND1. d The expression level of miR-329-3p in 30 CRC tissues and corresponding adjacent tissues was confirmed by qRT–PCR. e qRT-PCR was applied to determine the expression level of miR-329-3p in SW480 and LS1034 cells and normal colon NCM460 cell. f Spearman’s correlation analysis examined the correlations between the expression levels of CTNND1 mRNA and miR-329-3p in CRC tissues (P < 0.0001, r = − 0.6814). g, h The expression level of CTNND1 was measured by qRT-PCR after being transfected with miR-329-3p or anti-miR-329-3p for 48 h in SW480 and LS1034 cells. *P < 0.05, vs. control group

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