Fig. 1

Evaluation of the anti-glioma effect of single agent BKM120. a The antiproliferative effect of BKM120 as single agent treatment in eight GBM cell lines. Cell viability was measured with Alamar Blue. Data are presented as percentages relative to the vehicle control. b Images of colonies formed by eight GBM cell lines incubated with different concentrations of BKM120 for 14 days followed by Giemsa stain solution on the last day of incubation. c Western blot analysis showing blockage of PI3K pathway signaling by BKM120 in three cell lines. Three GBM cell lines were incubated with different concentrations of BKM120 for 24 h