Fig. 3
Validation of the BKM120 synergizing effects of candidate agents. a Cell viability of U251 cells upon treatment with BKM120 in the presence and absence of a fixed concentration of 6 candidate compounds. b Distribution of SI values of multiple GBM cell lines received treatment of BKM120 and targeted agents at different concentrations (2 μM, 10 μM) and a summary of top ranked 6 targeted agents c Images of colonies formed by U251 cells incubated with library inhibitors ± BKM120 for 14 days and Giemsa stained on the last day of incubation