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Fig. 4 | Cancer Cell International

Fig. 4

From: RACK1 promotes miR-302b/c/d-3p expression and inhibits CCNO expression to induce cell apoptosis in cervical squamous cell carcinoma

Fig. 4

miR-302b-3p, miR-302c-3p or miR-302d-3p induces apoptosis of CSCC cells and inhibits tumor growth in vivo by targeting CCNO. a The tumors collected at 40 days after CasKi cell transplantation into nude mice; b Tumor volume in nude mice transplanted with CasKi cells overexpressing miR-302b/c/d-3p. c Tumor weight in nude mice transplanted with CasKi cells overexpressing miR-302b/c/d-3p; d miR-302b/c/d-3p expression in mice detected by RT-qPCR; e The protein levels of CCNO, Bcl-2, CyclinD1, cleaved PARP, and cleaved caspase 3 in mice detected by Western blot analysis, with protein bands assessed. *p < 0.05 vs. mice treated with NC agomir. The values in the figure were all measurement data, and expressed as mean ± standard deviation. One-way ANOVA was used for data comparison among multiple groups, and Tukey’s post hoc test was conducted. Repeated measures ANOVA with Bonferroni post hoc test was used for data comparison among groups at different time points. N = 05. The experiment was repeated 3 times independently

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