From: Molecular mechanisms of long non-coding RNAs in anaplastic thyroid cancer: a systematic review
Author/year | LncRNA | Chromosomal location | Sample | Expression | Summary of findings | Refs. | |
---|---|---|---|---|---|---|---|
Cell line/tumor tissue | |||||||
Kim/2016 | LOC100507661 | 3q26.2 | C643 8505C | – | Up | ↑ Cell proliferation, migration, and invasiona | [11] |
Gu/2017 | GAS5 | 1q25.1 | – | 33 | Down | ↑ Cell cycle progression and proliferation probably by upregulating of CDK6 ↓ Survival rateb Poor prognosis | [12] |
Zhang/2019 | H19 | 11p15.5 | 8505C SW1736 KAT18 CAL62 | 19 | Up | ↑ Proliferation, migration, and invasion ↓ Apoptosis | [13] |
Wang/2018 | UCA1 | 19p13.12 | SW1736 KAT18 | 8 | Up | ↑ cell viability, proliferation, migration, and invasion via binding to miR-135a and regulation of c-myc expression | [14] |
Wang/2019 | HOTAIRM1 | 7p15.2 | – | 10 | Up | ↑ HOTAIRM1 expression during thyroid cancer development and progression | [15] |
Wang/2019 | PCA3 | 9q21.2 | – | 10 | Up | ↑ PCA3 expression during thyroid cancer development and progression | [15] |
Chen/2019 | HCP5 | 6p21.33 | SW1736 8305C ARO FRO | 19 | Up | ↑ Cell viability and ↓ Apoptosis by regulating the expression of miR-128-3p | [16] |
Credendino/2019 | KLHL14-AS (Klhl14)c | 18q12.1 | 8505C CAL62 | 9 | Down | ↑ Cell viability and ↓ Cpoptosis and differentiation by binding to miR-182-5p and miR-20a-5p and regulation of BCL2 and PAX8 expression | [17] |
Du/2018 | Linc00210 | 1q41 | 8505C | N/A | Up | ↑ Proliferation, migration, and invasion via binding to miR‐195‐5p and upregulation of IGF1R expression | [18] |
Hou/2018 | TNRC6C-AS1 | 17q25.3 | ARO Hth74 | N/A | Up | ↑ Proliferation, migration, and invasion via binding to miR‐129‐5p and upregulation of UNC5B expression | [19] |
Li/2017 | AK139328 | N/A | 8505C | N/A | Up | ↑ Cell viability, invasion, and cell cycle progression | [20] |
Song/2017 | LINC00312 | 3p25.3 | 8505C | 13 | Down | ↑ Proliferation, invasion, and migration by regulating of miR-197-3p expression and its target p120 | [21] |
Min/2018 | 8505C | N/A | Down | ↑ Proliferation and invasion by suppressing PI3K/AKT signaling pathway | [22] | ||
Liu/2018 | XIST | Xq13.2 | SW1736 KAT18 | – | Up | ↑ Proliferation through binding to miR-34a and upregulation of MET expression ↑ MET/PI3K/AKT signaling pathway | [23] |
Chen/2019 | SNHG7 | 9q34.3 | CAL62 | N/A | Up | ↑ Proliferation and cell cycle progression | [24] |
Liu/2018 | SNHG15 | 7p13 | 8505C | N/A | Down | ↑ Proliferation, migration, and invasion via upregulating miR-510-5p | [25] |
Han/2019 | ZFAS1 | 20q13.13 | CAL62 | 20 | Up | ↑ Proliferation and cell cycle progression | [26] |
Qin/2019 | MIR22HG | 17p13.3 | – | 11 | Down | ↓ MIR22HG is correlated to higher age, lymph node metastasis, and advanced TNM stages ↑ MIR22HG expression is associated with longer overall and disease-free survival time in thyroid cancer patients. | [27] |
Xiong/2017 | CASC2 | 10q26.11 | 8505C CAL62 HTH-83 | N/A | Down | ?↓ CASC2 expression is correlated with multifocality and advanced TNM stages ↑ CASC2 expression decreases the proliferation and arrests cell cycle at G0/G1 | [28] |
Yan/2019 | NEAT1 | 11q13.1 | 8505C SW1736 | 26 | Up | ↓ Cisplatin-resistance through regulating of miR-9-5p/SPAG9 axis | [29] |
LncRNAs related to CSCs propertiesd | |||||||
Hardin/2018 | ROR | 18q21.31 | THJ-16T | – | Up | ↑ CSC properties probably by modulating of OCT4, SOX2, and Nanog expression ↑ ROR expression in CSC clones of ATC line THJ-16T compared to the parental line ↑ Stem cell marker SOX2 and EMT marker SLUG | [30] |
Zhou/2016 | PVT1 | 8q24.21 | 8505C | 7 | Up | ↑ Cell cycle progression and proliferation by modulating of cyclin D1 and TSHR expression and also EZH2 recruitment | [31] |
Hardin/2018 | THJ-16T | – | Down | ↓ PVT1 expression in CSC clones of ATC line THJ-16T compared to the parental line ↑ Stem cell marker SOX2 and EMT marker SLUG | [30] | ||
Hardin/2018 | HOTAIR | 12q13.13 | THJ-16T | – | Down | ↓ HOTAIR expression in CSC clones of ATC line THJ-16T compared to the parental line ↑ Stem cell marker SOX2 and EMT marker SLUG | [30] |
Huang/2016 | SW1736 KAT18 | – | UP | ↑ Proliferation and invasion via upregulating of IQGAP1 expression | [32] | ||
Zhang/2017 | – | 35 | Down | ↓ MALAT1 expression in ATC tissue samples | [33] | ||
Samimi/2019 | MALAT1 | 11q13.1 | SW1736 C643 | – | Up | ↑ Mcl1 and cyclin D1 expression ↓ miR-363-3p expression | [34] |
Gou/2019 | SW1736 8505C | – | Up | ↑ Proliferation, migration, and invasion ↓ Apoptosis and autophagy via binding to miR‐200a‐3p and upregulation of FOXA1 expression | [35] | ||
Hardin/2018 | THJ-16T | – | Up | ↑ MALAT1 expression in CSC clones of ATC cell line compared to the parental line ↑ Stem cell marker SOX2 and EMT marker SLUG | [30] | ||
Liu/2017 | BANCR | 9q21.12 | 8505C | – | Up | ↑ Cell growth, colony formation ability, and cell cycle progression via regulating of BANCR/TSHR/CCND1 signaling pathway | [36] |
Liu/2019 | FOXD2-AS1 | 1p33 | 8305C CAL62 BHT101 | 10 | Up | ↑ FOXD2-AS1 expression in cell lines and tissues FOXD2-AS1 acts as a ceRNA for miR-7-5p and upregulates TERT expression, which increases the CSCs properties in thyroid cancer cells | [37] |
Wang/2018 | PTCSC3 | 14q13.3 | 8505C | 20 | Down | ↑ CSC properties by upregulating of STAT3, INO80, CD133, and ALDH1 ↑ Drug resistance by upregulating of MDR-1 via STAT3/INO80 pathway | [38] |
Fan/2013 | 8505C | – | Down | ↓ Apoptosis ↑ Cell growth and cell cycle progression probably by modulating of miR-574-5p | [39] | ||
Lu/2018 | MANCR | 10p15.1 | BHT101 | – | Up | ↓ Apoptosis ↑ Proliferation, colony formation, cell cycle progression G0 to G1, and EMT by modulating E-cadherin, N-cadherin, and β-catenin expression | [40] |
Pellecchia/2020 | PAR5 | 15q11.2 | 8505C ACT1 FB-1 FRO | 9 | Down | ↑ Proliferation, colony formation, and EMT through regulating EZH2 recruitment and E-cadherin expression | [41] |
Lei/2017 | TUG1 | 22q12.2 | SW1736 KAT18 | N/A | Up | ↑ Proliferation, colony formation, invasion, migration, and EMT through regulating miR-145/ZEB1 signaling pathway | [42] |