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Table 1 LncRNAs associated with ATC

From: Molecular mechanisms of long non-coding RNAs in anaplastic thyroid cancer: a systematic review

Author/year LncRNA Chromosomal location Sample Expression Summary of findings Refs.
Cell line/tumor tissue
Kim/2016 LOC100507661 3q26.2 C643
8505C
Up ↑ Cell proliferation, migration, and invasiona [11]
Gu/2017 GAS5 1q25.1 33 Down ↑ Cell cycle progression and proliferation probably by upregulating of CDK6
↓ Survival rateb
Poor prognosis
[12]
Zhang/2019 H19 11p15.5 8505C
SW1736
KAT18
CAL62
19 Up ↑ Proliferation, migration, and invasion
↓ Apoptosis
[13]
Wang/2018 UCA1 19p13.12 SW1736
KAT18
8 Up ↑ cell viability, proliferation, migration, and invasion via binding to miR-135a and regulation of c-myc expression [14]
Wang/2019 HOTAIRM1 7p15.2 10 Up ↑ HOTAIRM1 expression during thyroid cancer development and progression [15]
Wang/2019 PCA3 9q21.2 10 Up ↑ PCA3 expression during thyroid cancer development and progression [15]
Chen/2019 HCP5 6p21.33 SW1736
8305C
ARO
FRO
19 Up ↑ Cell viability and
↓ Apoptosis by regulating the expression of miR-128-3p
[16]
Credendino/2019 KLHL14-AS
(Klhl14)c
18q12.1 8505C
CAL62
9 Down ↑ Cell viability and
↓ Cpoptosis and differentiation by binding to miR-182-5p and miR-20a-5p and regulation of BCL2 and PAX8 expression
[17]
Du/2018 Linc00210 1q41 8505C N/A Up ↑ Proliferation, migration, and invasion via binding to miR‐195‐5p and upregulation of IGF1R expression [18]
Hou/2018 TNRC6C-AS1 17q25.3 ARO
Hth74
N/A Up ↑ Proliferation, migration, and invasion via binding to miR‐129‐5p and upregulation of UNC5B expression [19]
Li/2017 AK139328 N/A 8505C N/A Up ↑ Cell viability, invasion, and cell cycle progression [20]
Song/2017 LINC00312 3p25.3 8505C 13 Down ↑ Proliferation, invasion, and migration by regulating of miR-197-3p expression and its target p120 [21]
Min/2018    8505C N/A Down ↑ Proliferation and invasion by suppressing PI3K/AKT signaling pathway [22]
Liu/2018 XIST Xq13.2 SW1736
KAT18
Up ↑ Proliferation through binding to miR-34a and upregulation of MET expression
↑ MET/PI3K/AKT signaling pathway
[23]
Chen/2019 SNHG7 9q34.3 CAL62 N/A Up ↑ Proliferation and cell cycle progression [24]
Liu/2018 SNHG15 7p13 8505C N/A Down ↑ Proliferation, migration, and invasion via upregulating miR-510-5p [25]
Han/2019 ZFAS1 20q13.13 CAL62 20 Up ↑ Proliferation and cell cycle progression [26]
Qin/2019 MIR22HG 17p13.3 11 Down ↓ MIR22HG is correlated to higher age, lymph node metastasis, and advanced TNM stages
↑ MIR22HG expression is associated with longer overall and disease-free survival time in thyroid cancer patients.
[27]
Xiong/2017 CASC2 10q26.11 8505C
CAL62
HTH-83
N/A Down ?↓ CASC2 expression is correlated with multifocality and advanced TNM stages
↑ CASC2 expression decreases the proliferation and arrests cell cycle at G0/G1
[28]
Yan/2019 NEAT1 11q13.1 8505C
SW1736
26 Up ↓ Cisplatin-resistance through regulating of miR-9-5p/SPAG9 axis [29]
LncRNAs related to CSCs propertiesd
 Hardin/2018 ROR 18q21.31 THJ-16T Up ↑ CSC properties probably by modulating of OCT4, SOX2, and Nanog expression
↑ ROR expression in CSC clones of ATC line THJ-16T compared to the parental line
↑ Stem cell marker SOX2 and EMT marker SLUG
[30]
 Zhou/2016 PVT1 8q24.21 8505C 7 Up ↑ Cell cycle progression and proliferation by modulating of cyclin D1 and TSHR expression and also EZH2 recruitment [31]
Hardin/2018    THJ-16T Down ↓ PVT1 expression in CSC clones of ATC line THJ-16T compared to the parental line
↑ Stem cell marker SOX2 and EMT marker SLUG
[30]
Hardin/2018 HOTAIR 12q13.13 THJ-16T Down ↓ HOTAIR expression in CSC clones of ATC line THJ-16T compared to the parental line
↑ Stem cell marker SOX2 and EMT marker SLUG
[30]
Huang/2016    SW1736
KAT18
UP ↑ Proliferation and invasion via upregulating of IQGAP1 expression [32]
Zhang/2017    35 Down ↓ MALAT1 expression in ATC tissue samples [33]
Samimi/2019 MALAT1 11q13.1 SW1736
C643
Up ↑ Mcl1 and cyclin D1 expression
↓ miR-363-3p expression
[34]
Gou/2019    SW1736
8505C
Up ↑ Proliferation, migration, and invasion
↓ Apoptosis and autophagy via binding to miR‐200a‐3p and upregulation of FOXA1 expression
[35]
Hardin/2018    THJ-16T Up ↑ MALAT1 expression in CSC clones of ATC cell line compared to the parental line
↑ Stem cell marker SOX2 and EMT marker SLUG
[30]
Liu/2017 BANCR 9q21.12 8505C Up ↑ Cell growth, colony formation ability, and cell cycle progression via regulating of BANCR/TSHR/CCND1 signaling pathway [36]
Liu/2019 FOXD2-AS1 1p33 8305C
CAL62
BHT101
10 Up ↑ FOXD2-AS1 expression in cell lines and tissues
FOXD2-AS1 acts as a ceRNA for miR-7-5p and upregulates TERT expression, which increases the CSCs properties in thyroid cancer cells
[37]
Wang/2018 PTCSC3 14q13.3 8505C 20 Down ↑ CSC properties by upregulating of STAT3, INO80, CD133, and ALDH1
↑ Drug resistance by upregulating of MDR-1 via STAT3/INO80 pathway
[38]
Fan/2013    8505C Down ↓ Apoptosis
↑ Cell growth and cell cycle progression probably by modulating of miR-574-5p
[39]
Lu/2018 MANCR 10p15.1 BHT101 Up ↓ Apoptosis
↑ Proliferation, colony formation, cell cycle progression G0 to G1, and EMT by modulating E-cadherin, N-cadherin, and β-catenin expression
[40]
Pellecchia/2020 PAR5 15q11.2 8505C
ACT1
FB-1
FRO
9 Down ↑ Proliferation, colony formation, and EMT through regulating EZH2 recruitment and E-cadherin expression [41]
Lei/2017 TUG1 22q12.2 SW1736
KAT18
N/A Up ↑ Proliferation, colony formation, invasion, migration, and EMT through regulating miR-145/ZEB1 signaling pathway [42]
  1. AKT, AKT serine/threonine kinase; ALDH1, aldehyde dehydrogenase 1; BANCR, BRAF-activated non-protein coding RNA; BCL2, BCL2 apoptosis regulator; CASC2, cancer susceptibility candidate 2; CCND1, cyclin D1; CDK6, cycling-dependent kinase 6; ceRNA, competing endogenous RNA; c-myc, avian myeocytomatosis virus oncogene cellular homolog; CSC, cancer stem cell; EMT, epithelial to mesenchymal transition; EZH2, enhancer of zeste homolog 2; FOXA1, forkhead box protein A1; FOXD2-AS1, FOXD2 adjacent opposite strand RNA 1; GAS5, growth arrest special 5; HCP5, HLA complex P5; HOTAIR, HOX transcript antisense RNA; HOTAIRM1, hox antisense intergenic RNA myeloid 1; IGF1R, insulin like growth factor 1 receptor; INO80, INO80 complex ATPase subunit; IQGAP1, Ras GTPase-activating-like protein; Klhl14, kelch like family member 14; Linc00210, long intergenic non-protein coding RNA 210; LINC00312, long intergenic non-protein coding RNA 312; LncRNA, long noncoding RNA, MALAT1: metastasis-associated lung adenocarcinoma transcript 1; MANCR, mitotically associated long non coding RNA; Mcl1, myeloid cell leukemia 1; MDR-1, multidrug resistance protein 1; MET, MET protooncogene; miR, microRNA; MIR22HG, MIR22 host gene; NEAT1, nuclear paraspeckle assembly transcript 1; OCT4, octamer-binding transcription factor 4; PAR5, Prader Wili/Angelman region RNA 5; PAX8, paired box 1; PCA3, prostate cancer antigen 3; PI3K, phosphatidylinositol-3-kinas; PTCSC3, papillary thyroid carcinoma susceptibility candidate 3; PVT1, plasmacytoma variant translocation 1; ROR, regulator of reprogramming; SNHG15, small nucleolar RNA host gene 15; SNHG7, small nucleolar RNA host gene 7; SOX2, SRY-box transcription factor 2; SPAG9, sperm associated antigene 9; STAT3, signal transducer and activator of transcription 3; TNM, tumor-node-metastasis; TNRC6C-AS1, TNRC6C antisense RNA 1; TUG1, taurine up-regulated gene 1; UCA1, urothelial carcinoma-associated 1; UNC5B, unc-5 netrin receptor B; XIST, X inactive specific transcript; ZEB1, zinc finger E-box binding homeobox 1; ZFAS1, ZNFX1 antisense RNA 1
  2. a↑ Increase
  3. b↓ Decrease
  4. c In GeneCards database is named Klhl14
  5. dBased on the criteria defined in the text