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Table 1 LncRNAs associated with ATC

From: Molecular mechanisms of long non-coding RNAs in anaplastic thyroid cancer: a systematic review

Author/year

LncRNA

Chromosomal location

Sample

Expression

Summary of findings

Refs.

Cell line/tumor tissue

Kim/2016

LOC100507661

3q26.2

C643

8505C

Up

↑ Cell proliferation, migration, and invasiona

[11]

Gu/2017

GAS5

1q25.1

33

Down

↑ Cell cycle progression and proliferation probably by upregulating of CDK6

↓ Survival rateb

Poor prognosis

[12]

Zhang/2019

H19

11p15.5

8505C

SW1736

KAT18

CAL62

19

Up

↑ Proliferation, migration, and invasion

↓ Apoptosis

[13]

Wang/2018

UCA1

19p13.12

SW1736

KAT18

8

Up

↑ cell viability, proliferation, migration, and invasion via binding to miR-135a and regulation of c-myc expression

[14]

Wang/2019

HOTAIRM1

7p15.2

10

Up

↑ HOTAIRM1 expression during thyroid cancer development and progression

[15]

Wang/2019

PCA3

9q21.2

10

Up

↑ PCA3 expression during thyroid cancer development and progression

[15]

Chen/2019

HCP5

6p21.33

SW1736

8305C

ARO

FRO

19

Up

↑ Cell viability and

↓ Apoptosis by regulating the expression of miR-128-3p

[16]

Credendino/2019

KLHL14-AS

(Klhl14)c

18q12.1

8505C

CAL62

9

Down

↑ Cell viability and

↓ Cpoptosis and differentiation by binding to miR-182-5p and miR-20a-5p and regulation of BCL2 and PAX8 expression

[17]

Du/2018

Linc00210

1q41

8505C

N/A

Up

↑ Proliferation, migration, and invasion via binding to miR‐195‐5p and upregulation of IGF1R expression

[18]

Hou/2018

TNRC6C-AS1

17q25.3

ARO

Hth74

N/A

Up

↑ Proliferation, migration, and invasion via binding to miR‐129‐5p and upregulation of UNC5B expression

[19]

Li/2017

AK139328

N/A

8505C

N/A

Up

↑ Cell viability, invasion, and cell cycle progression

[20]

Song/2017

LINC00312

3p25.3

8505C

13

Down

↑ Proliferation, invasion, and migration by regulating of miR-197-3p expression and its target p120

[21]

Min/2018

  

8505C

N/A

Down

↑ Proliferation and invasion by suppressing PI3K/AKT signaling pathway

[22]

Liu/2018

XIST

Xq13.2

SW1736

KAT18

Up

↑ Proliferation through binding to miR-34a and upregulation of MET expression

↑ MET/PI3K/AKT signaling pathway

[23]

Chen/2019

SNHG7

9q34.3

CAL62

N/A

Up

↑ Proliferation and cell cycle progression

[24]

Liu/2018

SNHG15

7p13

8505C

N/A

Down

↑ Proliferation, migration, and invasion via upregulating miR-510-5p

[25]

Han/2019

ZFAS1

20q13.13

CAL62

20

Up

↑ Proliferation and cell cycle progression

[26]

Qin/2019

MIR22HG

17p13.3

11

Down

↓ MIR22HG is correlated to higher age, lymph node metastasis, and advanced TNM stages

↑ MIR22HG expression is associated with longer overall and disease-free survival time in thyroid cancer patients.

[27]

Xiong/2017

CASC2

10q26.11

8505C

CAL62

HTH-83

N/A

Down

?↓ CASC2 expression is correlated with multifocality and advanced TNM stages

↑ CASC2 expression decreases the proliferation and arrests cell cycle at G0/G1

[28]

Yan/2019

NEAT1

11q13.1

8505C

SW1736

26

Up

↓ Cisplatin-resistance through regulating of miR-9-5p/SPAG9 axis

[29]

LncRNAs related to CSCs propertiesd

 Hardin/2018

ROR

18q21.31

THJ-16T

Up

↑ CSC properties probably by modulating of OCT4, SOX2, and Nanog expression

↑ ROR expression in CSC clones of ATC line THJ-16T compared to the parental line

↑ Stem cell marker SOX2 and EMT marker SLUG

[30]

 Zhou/2016

PVT1

8q24.21

8505C

7

Up

↑ Cell cycle progression and proliferation by modulating of cyclin D1 and TSHR expression and also EZH2 recruitment

[31]

Hardin/2018

  

THJ-16T

Down

↓ PVT1 expression in CSC clones of ATC line THJ-16T compared to the parental line

↑ Stem cell marker SOX2 and EMT marker SLUG

[30]

Hardin/2018

HOTAIR

12q13.13

THJ-16T

Down

↓ HOTAIR expression in CSC clones of ATC line THJ-16T compared to the parental line

↑ Stem cell marker SOX2 and EMT marker SLUG

[30]

Huang/2016

  

SW1736

KAT18

UP

↑ Proliferation and invasion via upregulating of IQGAP1 expression

[32]

Zhang/2017

  

35

Down

↓ MALAT1 expression in ATC tissue samples

[33]

Samimi/2019

MALAT1

11q13.1

SW1736

C643

Up

↑ Mcl1 and cyclin D1 expression

↓ miR-363-3p expression

[34]

Gou/2019

  

SW1736

8505C

Up

↑ Proliferation, migration, and invasion

↓ Apoptosis and autophagy via binding to miR‐200a‐3p and upregulation of FOXA1 expression

[35]

Hardin/2018

  

THJ-16T

Up

↑ MALAT1 expression in CSC clones of ATC cell line compared to the parental line

↑ Stem cell marker SOX2 and EMT marker SLUG

[30]

Liu/2017

BANCR

9q21.12

8505C

Up

↑ Cell growth, colony formation ability, and cell cycle progression via regulating of BANCR/TSHR/CCND1 signaling pathway

[36]

Liu/2019

FOXD2-AS1

1p33

8305C

CAL62

BHT101

10

Up

↑ FOXD2-AS1 expression in cell lines and tissues

FOXD2-AS1 acts as a ceRNA for miR-7-5p and upregulates TERT expression, which increases the CSCs properties in thyroid cancer cells

[37]

Wang/2018

PTCSC3

14q13.3

8505C

20

Down

↑ CSC properties by upregulating of STAT3, INO80, CD133, and ALDH1

↑ Drug resistance by upregulating of MDR-1 via STAT3/INO80 pathway

[38]

Fan/2013

  

8505C

Down

↓ Apoptosis

↑ Cell growth and cell cycle progression probably by modulating of miR-574-5p

[39]

Lu/2018

MANCR

10p15.1

BHT101

Up

↓ Apoptosis

↑ Proliferation, colony formation, cell cycle progression G0 to G1, and EMT by modulating E-cadherin, N-cadherin, and β-catenin expression

[40]

Pellecchia/2020

PAR5

15q11.2

8505C

ACT1

FB-1

FRO

9

Down

↑ Proliferation, colony formation, and EMT through regulating EZH2 recruitment and E-cadherin expression

[41]

Lei/2017

TUG1

22q12.2

SW1736

KAT18

N/A

Up

↑ Proliferation, colony formation, invasion, migration, and EMT through regulating miR-145/ZEB1 signaling pathway

[42]

  1. AKT, AKT serine/threonine kinase; ALDH1, aldehyde dehydrogenase 1; BANCR, BRAF-activated non-protein coding RNA; BCL2, BCL2 apoptosis regulator; CASC2, cancer susceptibility candidate 2; CCND1, cyclin D1; CDK6, cycling-dependent kinase 6; ceRNA, competing endogenous RNA; c-myc, avian myeocytomatosis virus oncogene cellular homolog; CSC, cancer stem cell; EMT, epithelial to mesenchymal transition; EZH2, enhancer of zeste homolog 2; FOXA1, forkhead box protein A1; FOXD2-AS1, FOXD2 adjacent opposite strand RNA 1; GAS5, growth arrest special 5; HCP5, HLA complex P5; HOTAIR, HOX transcript antisense RNA; HOTAIRM1, hox antisense intergenic RNA myeloid 1; IGF1R, insulin like growth factor 1 receptor; INO80, INO80 complex ATPase subunit; IQGAP1, Ras GTPase-activating-like protein; Klhl14, kelch like family member 14; Linc00210, long intergenic non-protein coding RNA 210; LINC00312, long intergenic non-protein coding RNA 312; LncRNA, long noncoding RNA, MALAT1: metastasis-associated lung adenocarcinoma transcript 1; MANCR, mitotically associated long non coding RNA; Mcl1, myeloid cell leukemia 1; MDR-1, multidrug resistance protein 1; MET, MET protooncogene; miR, microRNA; MIR22HG, MIR22 host gene; NEAT1, nuclear paraspeckle assembly transcript 1; OCT4, octamer-binding transcription factor 4; PAR5, Prader Wili/Angelman region RNA 5; PAX8, paired box 1; PCA3, prostate cancer antigen 3; PI3K, phosphatidylinositol-3-kinas; PTCSC3, papillary thyroid carcinoma susceptibility candidate 3; PVT1, plasmacytoma variant translocation 1; ROR, regulator of reprogramming; SNHG15, small nucleolar RNA host gene 15; SNHG7, small nucleolar RNA host gene 7; SOX2, SRY-box transcription factor 2; SPAG9, sperm associated antigene 9; STAT3, signal transducer and activator of transcription 3; TNM, tumor-node-metastasis; TNRC6C-AS1, TNRC6C antisense RNA 1; TUG1, taurine up-regulated gene 1; UCA1, urothelial carcinoma-associated 1; UNC5B, unc-5 netrin receptor B; XIST, X inactive specific transcript; ZEB1, zinc finger E-box binding homeobox 1; ZFAS1, ZNFX1 antisense RNA 1
  2. a↑ Increase
  3. b↓ Decrease
  4. c In GeneCards database is named Klhl14
  5. dBased on the criteria defined in the text