Fig. 8

Activation of the MAPK signaling pathway in CC cells transfected with si-MAP7 1#/2# or MAP7-OE. a, c Western blot analysis of phosphorylated and total MEK and ERK expression in Caski and HeLa cells with MAP7 knockdown; and b, d the p-MEK/MEK and p-ERK/ERK ratios in Caski and HeLa cells. e Western blot analysis of phosphorylated and total MEK and ERK expression in C-33A cells with MAP7 overexpression; and f the p-MEK/MEK and p-ERK/ERK ratios in C-33A cells. n = 6; **p < 0.01 vs. controls (si-con or vector). MAP7 microtubule-associated protein 7, si-MAP7 siRNA targeting MAP7, si-con scrambled siRNA, MAP7-OE MAP7-overexpression vector