Fig. 1

SNHG6 promotes CC cell growth and enhances the radioresistance. a Expression of SNHG6 was probed in normal human cervical epithelial cell line (HCerEpiC) and CC cell lines (C-33 A, SiHa, HeLa, CaSki and HT-3) via qRT-PCR. b SNHG6 expression was inhibited by the specific shRNAs (sh-SNHG6#1 and sh-SNHG6#2). Non-targeted shRNA was used as the negative control (sh-NC). Transfection efficiency was evaluated after 48 h by qRT-PCR. c, d Cell proliferation was identified via colony formation assay and EdU assay after two cells were transfected with SNHG6-specific shRNAs or control shRNA. e, f JC-1 assay and TUNEL assay tested the apoptosis in the early phase or later phase after silencing of SNHG6 with specific shRNAs. g The sensitivity of SiHa and HeLa cells to radiation was evaluated after knockdown of SNHG6 by colony formation assay. *p < 0.05, **p < 0.01