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Fig. 4 | Cancer Cell International

Fig. 4

From: LncRNA SNHG6 enhances the radioresistance and promotes the growth of cervical cancer cells by sponging miR-485-3p

Fig. 4

SNHG6/miR-485-3p/STYX axis modulates CC cell growth. a The expression of STYX mRNA was identified via qRT-PCR when SNHG6 was silenced or miR-485-3p was overexpressed. b, c Inhibition efficiency of miR-485-3p and overexpression efficiency of STYX were assessed via qRT-PCR in SiHa and HeLa cells. d Colony formation assay probed the proliferation of SiHa and HeLa cells. Cells were transfected with sh-NC, sh-SNHG6#1, sh-SNHG6#1 + NC inhibitor, sh-SNHG6#1 + miR-485-3p inhibitor, sh-SNHG6#1 + pcDNA3.1-NC, sh-SNHG6#1 + pcDN3.1/STYX, respectively. e, f JC-1 assay and TUNEL assay tested the cell apoptosis of SiHa and HeLa cells. Cells were transfected with sh-NC, sh-SNHG6#1, sh-SNHG6#1 + NC inhibitor, sh-SNHG6#1 + miR-485-3p inhibitor, sh-SNHG6#1 + pcDNA3.1-NC, sh-SNHG6#1 + pcDN3.1/STYX, respectively. g Ionizing radiation investigated the cell radioresistance. Cells were transfected with sh-NC, sh-SNHG6#1, sh-SNHG6#1 + NC inhibitor, sh-SNHG6#1 + miR-485-3p inhibitor, sh-SNHG6#1 + pcDNA3.1-NC, sh-SNHG6#1 + pcDN3.1/STYX, respectively. *p < 0.05, **p < 0.01

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