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Table 1 Expression, clinical significance, and biological function of ALKBH5 in various cancers

From: The biological function of m6A demethylase ALKBH5 and its role in human disease

Cancer

Expression

Role

Biological Function

Target

References

Lung adenocarcinoma

Upregulated

Oncogene

Proliferation and invasion,

FOXM1

[11]

NSCLC

Upregulated

Oncogene

Proliferation, invasion, migration, and EMT

YAP

[13]

Proliferation, apoptosis and tumor growth

TIMP3

[20]

Pancreatic cancer

Downregulated

Tumor suppressor

Proliferation, invasion and migration

WIF-1

[16]

Motility

KCNK15-AS1

[26]

Colon cancer

Downregulated

Tumor suppressor

Invasion and metastasis

–

[17]

Gastric cancer

–

Oncogene

Invasion and metastasis

NEAT1

[19]

Glioblastoma

Upregulated

Oncogene

Migration and invasion

–

[15]

Proliferation, tumorigenesis

FOXM1

[25]

Epithelial ovarian cancer

Upregulated

Oncogene

Proliferation and invasion

EGFR-PIK3CA-AKT-mTOR, BCL-2

[21]

Clear cell renal cell carcinoma

Downregulated

–

–

–

[45]

Osteosarcoma

–

–

Proliferation and tumor growth

PVT1

[40]

Oral squamous cell carcinoma

–

–

Chemoresistance

FOXM1, NANOG

[46]