From: The biological function of m6A demethylase ALKBH5 and its role in human disease
Cancer | Expression | Role | Biological Function | Target | References |
---|---|---|---|---|---|
Lung adenocarcinoma | Upregulated | Oncogene | Proliferation and invasion, | FOXM1 | [11] |
NSCLC | Upregulated | Oncogene | Proliferation, invasion, migration, and EMT | YAP | [13] |
Proliferation, apoptosis and tumor growth | TIMP3 | [20] | |||
Pancreatic cancer | Downregulated | Tumor suppressor | Proliferation, invasion and migration | WIF-1 | [16] |
Motility | KCNK15-AS1 | [26] | |||
Colon cancer | Downregulated | Tumor suppressor | Invasion and metastasis | – | [17] |
Gastric cancer | – | Oncogene | Invasion and metastasis | NEAT1 | [19] |
Glioblastoma | Upregulated | Oncogene | Migration and invasion | – | [15] |
Proliferation, tumorigenesis | FOXM1 | [25] | |||
Epithelial ovarian cancer | Upregulated | Oncogene | Proliferation and invasion | EGFR-PIK3CA-AKT-mTOR, BCL-2 | [21] |
Clear cell renal cell carcinoma | Downregulated | – | – | – | [45] |
Osteosarcoma | – | – | Proliferation and tumor growth | PVT1 | [40] |
Oral squamous cell carcinoma | – | – | Chemoresistance | FOXM1, NANOG | [46] |