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Fig. 4 | Cancer Cell International

Fig. 4

From: TET2 suppresses nasopharyngeal carcinoma progression by inhibiting glycolysis metabolism

Fig. 4

TET2 interacts with PKM in cytoplasm to prevent PKM dimers formation. a H3K4me3 modification on the indicated promoter regions of PKM gene was examined by CHIP in CNE cells (control) or TET2-knockout (TET2-cas9) cells. b Half-life time of PKM mRNA was examined in CNE cells (control) or TET2-knockout (TET2-cas9) cells. c PKM protein expression was examined in CNE1 cells transfected with pcmv-flag-TET2. d PKM protein expression was examined in CNE1 cells transfected with pcmv-flag-TET2 or pcmv-flag-TET2Δ with deficiency of catalytic activity. e TET2 interacting with PKM was examined in the cytoplasm or nuclear of CNE1 cells. f PKM dimer was examined in DMSO or TET2-inhibitor treated-CNE1 cells. Data are represented as mean ± SD (n = 3; *represents P < 0.05)

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