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Fig. 1 | Cancer Cell International

Fig. 1

From: Evaluation of the upregulation and surface expression of hypoxanthine guanine phosphoribosyltransferase in acute lymphoblastic leukemia and Burkitt’s B cell lymphoma

Fig. 1

HPRT surface localization in Raji and normal cells. Fluorescent HPRT antibodies were compared against isotype controls to determine increase in HPRT expression on the surface of both Raji and normal lymphocytes. GAPDH and NF-kB were used as additional negative controls to ensure internal proteins were not stained and NaK was used as a positive membrane protein control. a Raji cells stained with a fluorescent anti-HPRT antibody experienced a significant shift (p-value < 0.0001) when compared to isotype controls. b Normal lymphocytes from healthy donors stained with fluorescent anti-HPRT antibodies did not experience a significant shift in the fluorescent population when compared to isotype controls. c Statistical analysis reveals a significant elevation of HPRT expression on the surface of Raji cells, and d an insignificant elevation of HPRT on healthy lymphocytes

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Cancer Cell International

ISSN: 1475-2867

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