Table 1 HPRT gene correlations to 109 genes in 79 human malignant B cell lines in the CCLE dataset

Direct correlation

XRCC2

DNA repair protein involved in homologous recombination.

 Breast cancer type 1 susceptibility protein

BRCA1

Tumor suppressor gene that maintains genomic stability via DNA damage repair, chromatin remodeling, transcriptional regulation and apoptosis.

 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha

PIK3CA

Involved in cell growth, survival, proliferation, motility and morphology. Also participates in cellular signaling in response to growth factors.

MSH2

Involved in mismatch repair system.

MSH6

Involved in mismatch repair system.

 Protein N-terminal glutamine amidohydrolase

WDYHV1

Involved in the N-end rule pathway in protein degradation.

 Adenylate kinase 7

AK7

Nucleoside monophosphate kinase that transfers phosphate groups between nucleoside triphosphates and monophosphates.

 Bleomycin hydrolase

BLMH

Cysteine peptidase, hydrolyzes homocysteine thiolactone

Inverse correlation

 Serine/threonine-protein kinase D2

PRKD2

Regulation of cell proliferation via MAP1/3 signaling.

 Prostaglandin G/H synthase 2

PTGS2

Production of inflammatory prostaglandins

TCF7L2

Involved in the Wnt signaling pathway and modulates MYC expression.

 Cadherin-1

CDH1

Involved in mechanisms regulating cell-cell adhesion, mobility, and proliferation.

 Interleukin-6 receptor

IL6R

Potent pleiotropic pro-inflammatory cytokine that regulates cell growth and differentiation.

 Melanocyte-stimulating hormone receptor

MC1R

Produces melanin pigment

 AMP deaminase 1

AMPD1

Energy metabolism

 Toll-like receptor 6

TLR6

Innate immune response to Gram-positive bacteria and fungi

 Brassinosteroid insensitive 1-associated receptor kinase 1

BAK1

Controls the expression of genes associated with innate immunity in the absence of pathogens or elicitors.