Fig. 5
From: Transgelin interacts with PARP1 in human colon cancer cells
Proposed model of the transgelin mechanisms involved in promoting colon cancer metastasis. Once the cancer cells receive signals from the tumor micro-environment, transgelin directly remodels the cytoskeleton. It also binds to the PARP1 forming a complex which translocates into the nucleus where it regulates the expression of the key genes. Subsequently, the Rho signaling pathway is stimulated and initiates cytoskeletal remodeling which promotes colon cancer metastasis