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Fig. 5 | Cancer Cell International

Fig. 5

From: Long non-coding RNA SNHG6 regulates the sensitivity of prostate cancer cells to paclitaxel by sponging miR-186

Fig. 5

SNHG6 mediated the proliferation, migration, and invasion of PTX-resistant PCa cells through miR-186. a QRT-PCR was utilized for the assessment of miR-186 expression in PC-3/R and DU145/R cells transfected with anti-NC or anti-miR-186. b–f PC-3/R and DU145/R cells were transfected with si-NC, si-SNHG6, si-SNHG6 + anti-NC, or si-SNHG6 + anti-miR-186. b MTT assay was conducted for the detection of the proliferation of PC-3/R and DU145/R cells. c, d Transwell assay was executed to determine the migration and invasion of PC-3/R and DU145/R cells. e, f western blot analysis was used to detect the levels of CyclinD1, MMP9, Vimentin, and E-cadherin in PC-3/R and DU145/R cells. *P < 0.05, **P < 0.001 and ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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