TY - JOUR AU - Lu, Chengli AU - Ma, Zhiyuan AU - Cheng, Xiaoming AU - Wu, Huichao AU - Tuo, Biguang AU - Liu, Xuemei AU - Li, Taolang PY - 2020 DA - 2020/08/06 TI - Pathological role of ion channels and transporters in the development and progression of triple-negative breast cancer JO - Cancer Cell International SP - 377 VL - 20 IS - 1 AB - Breast cancer is a common malignancy in women. Among breast cancer types, triple-negative breast cancer (TNBC) tends to affect younger women, is prone to axillary lymph node, lung, and bone metastases; and has a high recurrence rate. Due to a lack of classic biomarkers, the currently available treatments are surgery and chemotherapy; no targeted standard treatment options are available. Therefore, it is urgent to find a novel and effective therapeutic target. As alteration of ion channels and transporters in normal mammary cells may affect cell growth, resulting in the development and progression of TNBC, ion channels and transporters may be promising new therapeutic targets for TNBC. This review summarizes ion channels and transporters related to TNBC and may provide new tumor biomarkers and help in the development of novel targeted therapies. SN - 1475-2867 UR - https://doi.org/10.1186/s12935-020-01464-9 DO - 10.1186/s12935-020-01464-9 ID - Lu2020 ER -