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Fig. 3 | Cancer Cell International

Fig. 3

From: OIP5-AS1 contributes to tumorigenesis in hepatocellular carcinoma by miR-300/YY1-activated WNT pathway

Fig. 3

Upregulation of miR-300 suppressed tumorigenesis in HCC. ac Cell proliferation ability was assessed in cells treated with miR-300 mimics or NC mimics by CCK-8, colony formation and EdU assays. d The effect of miR-300 upregulation on cell apoptosis was evaluated by caspase-3 activity test. e Cell cycle distribution was measured by flow cytometry analysis in HCC cells responding to the increased level of miR-300. f The proteins relevant to cell apoptosis and cell cycle were determined via western blot. g, h The growth curve and weight of tumors originated from MHCC97H cells transfected with control or miR-300 agomir. i The staining of Ki67 in above tumors was determined by IHC assay. **P < 0.01

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