Fig. 3
From: Stigmasterol sensitizes endometrial cancer cells to chemotherapy by repressing Nrf2 signal pathway
Stigmasterol is the Nrf2 inhibitor candidate. Network pharmacology screens the possible inhibitor candidate. a the molecular structure of stigmasterol. White represents carbon atom, blue is hydrogen atom, red is oxygen atom. The predicted human Nrf2 structural domain 2FLU and 5F72 (b) and mouse Nrf2 domain 3WN7 and 4ZY3 (c) with which stigmasterol binds. It shows the key amino acid of above structural domain interacting with stigmasterol, including human (d) and mouse (e) Nrf2 protein