Fig. 1

Circ_0007841 elevates the malignant behaviors of MM cells. a The enrichment of circ_0007841 was examined in BM-derived plasma cells of MM patients and normal volunteers by qRT-PCR. b The expression of circ_0007841 was measured in MM cell lines and normal plasma cell line nPCs by qRT-PCR. c, d The level of circ_0007841 was detected in H929 and OPM2 cells transfected with si-NC, si-circ_0007841#1, si-circ_0007841#2 or si-circ_0007841#3 by qRT-PCR. e–k MM cells were transfected with si-NC or si-circ_0007841#1. e, f CCK8 assay was employed to assess the proliferation ability of MM cells. g Colony formation assay was performed for the determination of cell proliferation ability in transfected MM cells. h Flow cytometry was carried out to detect the influence of circ_0007841 silencing on the cycle of MM cells. i, j The metastasis ability of MM cells was evaluated by transwell assays. k The apoptosis of MM cells was analyzed by flow cytometry. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001