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Fig. 5 | Cancer Cell International

Fig. 5

From: Circ_0007841 promotes the progression of multiple myeloma through targeting miR-338-3p/BRD4 signaling cascade

Fig. 5

BRD4 overexpression attenuates the effects of miR-338-3p accumulation on MM cells. a–i MM cells were transfected with miR-NC, miR-338-3p, miR-338-3p + pcDNA or miR-338-3p + BRD4. a qRT-PCR was employed to measure the expression of BRD4 in MM cells. b, c CCK8 assay was applied to assess the proliferation ability of MM cells. d Colony formation assay was performed to analyze the influences of miR-338-3p and BRD4 on the proliferation of MM cells. e, f Flow cytometry was conducted to detect the cell cycle of MM cells. g, h Transwell assays were performed to detect the metastasis of MM cells. i The apoptosis rate of MM cells was examined by flow cytometry. *P < 0.05, **P < 0.01, ***P < 0.001

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