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Fig. 10 | Cancer Cell International

Fig. 10

From: Synergy between hemagglutinin 2 (HA2) subunit of influenza fusogenic membrane glycoprotein and oncolytic Newcastle disease virus suppressed tumor growth and further enhanced by Immune checkpoint PD-1 blockade

Fig. 10

The impact of PD-1 blockade on the level of cytokine secretion using ELISA assay as described in “Methods” section. a IFN-γ level in NDV-HA2 and NDV groups was highly increased (P < 0.001) when coupled with PD-1 blockade. Except for iNDV-HA2, treatment with anti-PD-1 did not enhance the level of IFN-γ secretion among other groups. b The level of IL-12 secretion increased in NDV-HA2, iNDV-HA2, iNDV (P < 0.001), and NDV (P < 0.01) when treated with anti-PD-1 in comparison with isotype control groups. Data points represent means ± SD of triplicate measurements for three mice. *P < 0.05, **P < 0.01, ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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