Prognostic value of a five-lncRNA signature in esophageal squamous cell carcinoma

Table 4 Cox regression analysis of the signature for the ESCC patients from the three datasets

		Univariable analysis				Multivariable analysis
Variables		HR	95% CI of HR		P	HR	95% CI of HR		P
Variables		HR	Lower	Upper	P	HR	Lower	Upper	P
GSE53624 dataset(n = 119)
Age	> 61 vs. ≤ 61	1.643	1.024	2.636	0.040	1.441	0.894	2.322	0.134
Sex	Male vs. Female	0.827	0.468	1.461	0.513	0.782	0.440	1.391	0.403
TNM stage	III, IV vs. I, II	1.901	1.226	2.948	0.004	2.017	1.288	3.159	0.002
lncRNA signature	High risk vs. low risk	3.264	1.998	5.331	< 0.001	3.502	2.131	5.756	< 0.001
RNA seq set (n = 98)
Age	> 61 vs. ≤ 61	1.287	0.744	2.225	0.367	1.314	0.711	2.430	0.383
Sex	Male vs. Female	1.534	0.818	2.875	0.182	1.116	0.561	2.221	0.754
TNM stage	III, IV vs. I, II	1.795	1.152	2.796	0.010	1.629	0.887	2.991	0.115
lncRNA signature	High risk vs. low risk	1.994	1.139	3.491	0.016	1.032	1.002	1.062	0.035
Independent qPCR validation set (n = 84)
Age	> 61 vs. ≤ 61	0.949	0.892	1.011	0.105	0.961	0.893	1.034	0.289
Sex	Male vs. Female	0.797	0.352	1.804	0.585	0.872	0.381	1.997	0.747
TNM stage	III, IV vs. I, II	2.699	1.607	4.534	0.000	4.910	2.133	11.302	< 0.001
lncRNA signature	High risk vs. low risk	2.981	1.235	7.192	0.015	2.945	1.210	7.168	0.017

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