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Fig. 6 | Cancer Cell International

Fig. 6

From: LncRNA KCNQ1OT1 sponges miR-15a to promote immune evasion and malignant progression of prostate cancer via up-regulating PD-L1

Fig. 6

KCNQ1OT1 essentially maintained the malignant phenotypes of PC cells by targeting miR-15a. a–c The apoptosis (a), migration (b), and invasion (c) of indicated PC cells were examined by Annexin V/PI dual staining followed by flow cytometry, wound healing assay, and Transwell assay, respectively. d The protein levels of Ras, p-ERK1/2, ERK1/2, Snail, E-cadherin, N-cadherin and MMP-9 were examined by western blot. DU145 and PC-3 cells were not transfected or transfected with shNC, shKCNQ1OT1, shKCNQ1OT1 + inhibitor NC, or shKCNQ1OT1 + miR-15a inhibitor, respectively. *P < 0.05 and **P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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