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Fig. 3 | Cancer Cell International

Fig. 3

From: Downregulation of long non-coding RNA MAFG-AS1 represses tumorigenesis of colorectal cancer cells through the microRNA-149-3p-dependent inhibition of HOXB8

Fig. 3

LncRNA MAFG-AS1 specifically binds to miR-149-3p and downregulates miR-149-3p expression. a The predicative binding sites between miR-149-3p and lncRNA MAFG-AS1. b The subcellular localization of lncRNA MAFG-AS1 predicted online. c The expression of lncRNA MAFG-AS1 in HCT116 cells detected by FISH assay (scale bar = 25 µm). d The binding between lncRNA MAFG-AS1 and miR-149-3p detected by dual luciferase reporter gene assay. e The binding of lncRNA MAFG-AS1 and miR-149-3p to Ago2 detected by RIP assay. f The expression of miR-149-3p in HCT116 and LoVo cells determined by RT-qPCR. Data between two groups were compared by unpaired t test. The experiment was repeated 3 times independently

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Cancer Cell International

ISSN: 1475-2867

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