Table 3 Relationship of TNFAIP8 polymorphisms and ovarian cancer risk
From: TNFAIP8 variants as potential epidemiological and predictive biomarkers in ovarian cancer
Variables | Cases (%) n = 210 | Controls (%) n = 231 | COR (95% CI) | P | AOR (95% CI) | P* |
|---|---|---|---|---|---|---|
rs11064 | ||||||
 Codominant | ||||||
  AA | 145 (69.0) | 145 (62.8) | 1.000 | 0.040 | 1.000 | 0.048 |
  AG | 62 (29.5) | 15 (6.5) | 0.873 (0.579–1.317) | 0.518 | 0.905 (0.598–1.370) | 0.636 |
  GG | 3 (1.4) |  | 0.200 (0.057–0.706) | 0.012 | 0.205 (0.058–0.726) | 0.014 |
 Dominant | ||||||
  AA | 145 (69.0) | 145 (62.8) | 1.000 |  | 1.000 |  |
  AG + GG | 65 (31.0) | 86 (37.2) | 0.756 (0.509–1.123) | 0.166 | 0.782 (0.524–1.165) | 0.226 |
 Recessive | ||||||
  AA + AG | 207 (98.6) | 216 (93.5) | 1.000 |  | 1.000 |  |
  GG | 3 (1.4) | 15 (6.5) | 0.209 (0.060–0.731) | 0.014 | 0.212 (0.060–0.744) | 0.016 |
rs1045241 | ||||||
 Codominant | ||||||
  CC | 137 (65.2) | 154 (66.7) | 1.000 | 0.276 | 1.000 | 0.214 |
  CT | 67 (31.9) | 64 (27.7) | 1.177 (0.779–1.778) | 0.440 | 1.216 (0.801–1.846) | 0.359 |
  TT | 6 (2.9) | 13 (5.6) | 0.519 (0.192–1.402) | 0.196 | 0.497 (0.183–1.350) | 0.170 |
 Dominant | ||||||
  CC | 137 (65.2) | 154 (66.7) | 1.000 |  | 1.000 |  |
  CT + TT | 73 (34.8) | 77 (33.3) | 1.066 (0.718–1.581) | 0.752 | 1.089 (0.731–1.622) | 0.674 |
 Recessive | ||||||
  CC + CT | 204 (97.1) | 218 (94.4) | 1.000 |  | 1.000 |  |
  TT | 6 (2.9) | 13 (5.6) | 0.493 (0.184–1.322) | 0.160 | 0.468 (0.174–1.263) | 0.134 |
rs1045242 | ||||||
 Codominant | ||||||
  AA | 135 (64.3) | 175 (75.8) | 1.000 | 0.026 | 1.000 | 0.025 |
  AG | 67 (31.9) | 52 (22.5) | 1.670 (1.091–2.558) | 0.018 | 1.703 (1.108–2.618) | 0.015 |
  GG | 8 (3.8) | 4 (1.7) | 2.593 (0.765–8.791) | 0.126 | 2.490 (0.731–8.484) | 0.145 |
 Dominant | ||||||
  AA | 135 (64.3) | 175 (75.8) | 1.000 |  | 1.000 |  |
  AG + GG | 75 (35.7) | 56 (24.2) | 1.736 (1.149–2.623) | 0.009 | 1.761 (1.162–2.670) | 0.008 |
 Recessive | ||||||
  AA + AG | 202 (96.2) | 227 (98.3) | 1.000 |  | 1.000 |  |
  GG | 8 (3.8) | 4 (1.7) | 2.248 (0.667–7.576) | 0.191 | 2.151 (0.635–7.286) | 0.218 |