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Fig. 2 | Cancer Cell International

Fig. 2

From: CircZFR functions as a sponge of miR-578 to promote breast cancer progression by regulating HIF1A expression

Fig. 2

CircZFR silencing suppressed BC progression in vitro and in vivo. a, b qRT-PCR for circZFR expression in MCF7 and BT-549 cell lines transduced with sh-NC, sh-circZFR#1, sh-circZFR#2 or sh-circZFR#3. CCK-8 assay for cell viability (c), colony formation assay for cell colony formation (d, e), flow cytometry for cell apoptosis (f, g) in sh-NC-infected or sh-circZFR-transduced MCF7 and BT-549 cell lines. h, i sh-NC-infected or sh-circZFR-transduced BT-549 cell line was subcutaneously injected into the nude mice (n = 6 per group), followed by the measurement of tumor volume and weight and the capture of representative pictures. *P < 0.05

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