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Fig. 5 | Cancer Cell International

Fig. 5

From: CircZFR functions as a sponge of miR-578 to promote breast cancer progression by regulating HIF1A expression

Fig. 5

MiR-578 overexpression hindered BC progression in vitro. a qRT-PCR for miR-578 expression in 70 pairs of tumor tissues and adjacent normal tissues. b Correlation between miR-578 expression and circZFR level in BC tissues using the Spearman test. c MiR-578 expression by qRT-PCR in MCF10A, MCF7, BT-549, MDA-MB-231 and MDA-MB-453 cell lines. MCF7 and BT-549 cell lines were transfected with miR-NC mimic or miR-578 mimic, followed by the determination of cell viability by CCK-8 assay (d), colony formation using a standard colony formation assay (e), cell apoptosis by flow cytometry (f), cell migration (g) and invasion (h) by transwell assay, glucose uptake, lactate product and ATP level using assay kits (i–k). *P < 0.05

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Cancer Cell International

ISSN: 1475-2867

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