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Fig. 8 | Cancer Cell International

Fig. 8

From: CircZFR functions as a sponge of miR-578 to promote breast cancer progression by regulating HIF1A expression

Fig. 8

The repression of miR-578 up-regulation on BC progression in vitro was mediated by HIF1A. a HIF1A protein level by western blot in MCF7 and BT-549 cell lines transfected with vector or HIF1A. MCF7 and BT-549 cell lines were transfected with miR-NC mimic + vector, miR-578 mimic + vector or miR-578 mimic + HIF1A, followed by the determination of cell viability by CCK-8 assay (b), cell apoptosis by flow cytometry (c), cell migration and invasion by transwell assay (d, e), glucose uptake, lactate product and ATP level using assay kits (f–h). vector: negative control plasmid, HIF1A: recombinant HIF1A overexpressing plasmid. *P < 0.05

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Cancer Cell International

ISSN: 1475-2867

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