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Fig. 4 | Cancer Cell International

Fig. 4

From: Circ_002117 binds to microRNA-370 and promotes endoplasmic reticulum stress-induced apoptosis in gastric cancer

Fig. 4

Circ_002117 binds to miR-370. a circ_002117 binding sites on miR-370 predicted by CircInteractome. b Targeting relationship between miR-370 and circ_002117 determined by dual luciferase assay. c Interaction between circ_002117 and Ago2 determined by RIP. d Interaction between circ_002117 and miR-370 determined by RIP. e Subcellular co-localization of circ_002117 and miR-370 determined by FISH (×500). f miR-370 expression in AGS cells after overexpression of circ_002117 determined by RT-qPCR. *p < 0.05 vs. mimic NC or IgG. #p < 0.05 vs. NC-bio-probe or oe-NC. Data are shown as the mean ± standard deviation. Data between two groups were analyzed unpaired t-test. Data among multiple groups was analyzed by Tukey’s test-corrected ANOVA. The experiment was in triplicate

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